Diabetes Care
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Diabetes Care, Vol 13, Issue 6 576-581, Copyright © 1990 by American Diabetes Association

ARTICLES

Hybrid insulin receptors. Molecular mechanisms of negative-dominant mutations in receptor-mediated insulin resistance

J Whittaker, MA Soos and K Siddle
Department of Medicine, Health Sciences Center, State University of New York, Stony Brook.

Certain syndromes of extreme insulin resistance are the result of negative-dominant mutations of the insulin receptor. The insulin-receptor heterotetramer appears to be the minimal functional unit for insulin signal transduction probably due to a requirement for intersubunit interactions. The observation that insulin and insulinlike growth factor I receptors can be found in hybrid heterotetramers suggests that insulin receptors can be composed of heterodimers that are the products of separate genes. Such a structure provides a potential molecular mechanism for negative-dominant receptor mutations.
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Copyright © 1990 by the American Diabetes Association.