Diabetes Care, Vol 15, Issue 8 1002-1008, Copyright © 1992 by American Diabetes Association

ARTICLES

High systolic blood pressure increases prevalence and severity of retinopathy in NIDDM patients

M Cignarelli, ML De Cicco, A Damato, A Paternostro, S Pagliarini, S Santoro, L Cardia, G De Pergola and R Giorgino
Istituto di Clinica Medica, Endocrinologia e Malattie Metaboliche, Universita di Bari, Italy.

OBJECTIVE--To determine whether the severity of retinopathy is higher in a group of NIDDM patients with sBP greater than or equal to 140 mmHg compared with NIDDM patients with sBP less than 140 mmHg. RESEARCH DESIGN AND METHODS--Ophthalmoscopy and FAG were conducted among a group of NIDDM patients with either a sBP above (n = 54) or below (n = 55) 140 mmHg. The groups were matched according to diabetes duration, metabolic control (HbA1c), and AER. RESULTS--Patients with sBP greater than 140 mmHg had a higher prevalence of retinopathy, as established according to a rating scale (4.9 +/- 3.8 vs. 3.2 +/- 3.3, P less than 0.02); furthermore, their BMI values were higher (28.1 +/- 4.5 vs. 24.9 +/- 4.1 kg/m2, P less than 0.001). The group of normotensive subjects showed the highest rate of low grading (0-2) values. However, the highest prevalence rates of 8-10 grading values (proliferative retinopathy) were found in the hypertensive group. CONCLUSIONS--These data suggest that sBP values greater than or equal to 140 mmHg favor the onset of retinopathy in NIDDM patients during their 1st 10 yr of disease.
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