Diabetes Care, Vol 15, Issue 8 1050-1052, Copyright © 1992 by American Diabetes Association

ARTICLES

MPO activity and generation of active O2 species in leukocytes from poorly controlled diabetic patients

N Sato, H Shimizu, K Suwa, Y Shimomura, I Kobayashi and M Mori
Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.

OBJECTIVE--This study was undertaken to determine which part of ROI generation is reduced in the neutrophils from patients with NIDDM. RESEARCH DESIGN AND METHODS--Superoxide anion (O2-) production, LDCL activity in response to opsonized zymosan, and MPO activity were measured in leukocytes of poorly controlled NIDDM patients (FBG greater than 8.89 mM, HbA1 greater than 10%). RESULTS--In diabetic subjects, both O2- production and LDCL activity assessed with initial slope gradient and peak value were significantly reduced. MPO activity was also decreased in diabetic subjects, and there was a significant correlation between HbA1 levels and MPO activity of diabetic subjects. CONCLUSIONS--This study demonstrated that every step in leukocyte ROI generation should be reduced in the leukocytes from poorly controlled diabetic patients.
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