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Diabetes Care, Vol 16, Issue 1 184-186, Copyright © 1993 by American Diabetes Association

ARTICLES

Successful treatment of severe refractory sulfonylurea-induced hypoglycemia with octreotide

AJ Krentz, PJ Boyle, KM Justice, AD Wright and DS Schade
Diabetic Clinic, General Hospital, Birmingham, United Kingdom.

OBJECTIVE--To test the clinical use of octreotide in the treatment of sulfonylurea-induced hypoglycemia. RESEARCH DESIGN AND METHODS--A case is reported of sulfonylurea-induced hypoglycemic coma in a nondiabetic subject, which was complicated by relapse of hypoglycemia after resuscitation with intravenous dextrose. Subcutaneous octreotide, 50 micrograms 12 hourly, suppressed stimulated endogenous insulin secretion, thereby preventing a further recurrence of hypoglycemia. RESULTS--No adverse effects of treatment were observed. CONCLUSIONS--These results suggest a significant role for octreotide as an adjunct to intravenous dextrose in the management of severe and refractory cases of sulfonylurea-induced hypoglycemia.
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Copyright © 1993 by the American Diabetes Association.