Diabetes Care, Vol 16, Issue 7 1022-1025, Copyright © 1993 by American Diabetes Association

ARTICLES

Prevalence of cardiovascular and renal complications in older adults with normal or impaired glucose tolerance or NIDDM. A population-based study

DL Wingard, EL Barrett-Connor, C Scheidt-Nave and JB McPhillips
University of California, Department of Family & Preventive Medicine, La Jolia, San Diego 92093-0607.

OBJECTIVE--To determine the prevalence of CVD and renal disease by glucose tolerance status in a population-based study. RESEARCH DESIGN AND METHODS--The study consisted of 991 men and 1243 women, aged 50-89 yr, living in the upper-middle class community of Rancho Bernardo, CA. All participants received a standard OGTT between 1984 and 1987. RESULTS--A total of 159 men and 158 women had NIDDM, whereas 237 men and 348 women had IGT. Age-adjusted prevalence of complications generally was highest in those who were previously diagnosed with NIDDM. A significant correlation was observed between increases in the prevalence of complications and increases in glucose intolerance for microproteinuria, macroproteinuria, and myocardial infarction (borderline), as well as for stroke and claudication in men and myocardial infarction and stroke in women. In men with IGT or NIDDM, the age-adjusted prevalence of proteinuria and CVD was highest when other complications were present whereas in women such a prevalence was highest when other complications were absent. In men with diabetes, microproteinuria was associated with duration of disease. CONCLUSIONS--Prevalent CVD and renal disease were increased in adults with NIDDM and elevated in adults with IGT compared to those with normal glucose tolerance. The prevalence of complications in NIDDM subjects in this population-based study was substantially lower than that reported for clinic-based diabetic populations.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				Y. S. Levitzky, M. J. Pencina, R. B. D'Agostino, J. B. Meigs, J. M. Murabito, R. S. Vasan, and C. S. Fox Impact of Impaired Fasting Glucose on Cardiovascular Disease: The Framingham Heart Study J. Am. Coll. Cardiol., January 22, 2008; 51(3): 264 - 270. [Abstract] [Full Text] [PDF]

				M. A. Bethel, F. A. Sloan, D. Belsky, and M. N. Feinglos Longitudinal Incidence and Prevalence of Adverse Outcomes of Diabetes Mellitus in Elderly Patients Arch Intern Med, May 14, 2007; 167(9): 921 - 927. [Abstract] [Full Text] [PDF]

				R. Marin, P. Rodriguez, S. Tranche, J. Redon, F. Morales-Olivas, A. Galgo, M. A. Brito, J. Mediavilla, J. V. Lozano, C. Filozof, et al. Prevalence of Abnormal Urinary Albumin Excretion Rate in Hypertensive Patients with Impaired Fasting Glucose and Its Association with Cardiovascular Disease J. Am. Soc. Nephrol., December 1, 2006; 17(12_suppl_3): S178 - S188. [Abstract] [Full Text] [PDF]

				N. Chaowalit, A. L. Arruda, R. B. McCully, K. R. Bailey, and P. A. Pellikka Dobutamine Stress Echocardiography in Patients With Diabetes Mellitus: Enhanced Prognostic Prediction Using a Simple Risk Score J. Am. Coll. Cardiol., March 7, 2006; 47(5): 1029 - 1036. [Abstract] [Full Text] [PDF]

				P. Raggi, L. J. Shaw, D. S. Berman, and T. Q. Callister Prognostic value of coronary artery calcium screening in subjects with and without diabetes J. Am. Coll. Cardiol., May 5, 2004; 43(9): 1663 - 1669. [Abstract] [Full Text] [PDF]

				S. Vijan and R. A. Hayward Pharmacologic Lipid-Lowering Therapy in Type 2 Diabetes Mellitus: Background Paper for the American College of Physicians Ann Intern Med, April 20, 2004; 140(8): 650 - 658. [Abstract] [Full Text] [PDF]

				S. Vijan and R. A. Hayward Treatment of Hypertension in Type 2 Diabetes Mellitus: Blood Pressure Goals, Choice of Agents, and Setting Priorities in Diabetes Care Ann Intern Med, April 1, 2003; 138(7): 593 - 602. [Abstract] [Full Text] [PDF]

				P. B. Leurs, R. P. Stolk, K. Hamulyak, R. van Oerle, D. E. Grobbee, and B. H. R. Wolffenbuttel Tissue Factor Pathway Inhibitor and Other Endothelium-Dependent Hemostatic Factors in Elderly Individuals With Normal or Impaired Glucose Tolerance and Type 2 Diabetes Diabetes Care, August 1, 2002; 25(8): 1340 - 1345. [Abstract] [Full Text] [PDF]

				L. V. Franse, M. Di Bari, R. I. Shorr, H. E. Resnick, J. T. M. van Eijk, D. C. Bauer, A. B. Newman, and M. Pahor Type 2 Diabetes in Older Well-Functioning People: Who Is Undiagnosed?: Data from the Health, Aging, and Body Composition Study Diabetes Care, December 1, 2001; 24(12): 2065 - 2070. [Abstract] [Full Text] [PDF]

				D. A. Bennett Diabetes and Change in Cognitive Function Arch Intern Med, January 24, 2000; 160(2): 141 - 143. [Full Text] [PDF]

				S. M. Grundy, I. J. Benjamin, G. L. Burke, A. Chait, R. H. Eckel, B. V. Howard, W. Mitch, S. C. Smith Jr, and J. R. Sowers Diabetes and Cardiovascular Disease : A Statement for Healthcare Professionals From the American Heart Association Circulation, September 7, 1999; 100(10): 1134 - 1146. [Full Text] [PDF]

				S. M. Haffner The Importance of Hyperglycemia in the Nonfasting State to the Development of Cardiovascular Disease Endocr. Rev., October 1, 1998; 19(5): 583 - 592. [Abstract] [Full Text]