Diabetes Care, Vol 17, Issue 11 1300-1306, Copyright © 1994 by American Diabetes Association

ARTICLES

Comparison of pharmacokinetics and pharmacodynamics of short- and long-term glyburide therapy in NIDDM

LA Jaber, EJ Antal, RL Slaughter and IR Welshman
Department of Pharmacy Practice, Wayne State University, Detroit, Michigan.

OBJECTIVE--To examine the pharmacokinetics and pharmacodynamics of glyburide after single- and multiple-dose administration in patients with type II diabetes. RESEARCH DESIGN AND METHODS--Twenty patients with type II diabetes between 40 and 70 years of age participated in the study. A 24-h pharmacokinetic evaluation including a 4-h Sustacal tolerance test was conducted before instituting glyburide therapy (baseline), after the first 2.5-mg test dose of glyburide and at weeks 6 and 12 of chronic glyburide therapy. Glyburide doses were titrated with a target goal of achieving a fasting plasma glucose of < or = 7.8 mmol/l or to reach maximum daily doses of 20 mg. RESULTS--A significant prolongation in the elimination half-life (t1/2: week 0, 4.0 +/- 1.9 h; week 6, 13.7 +/- 10.5 h; and week 12, 12.1 +/- 8.2 h) and an increased volume of distribution of glyburide was observed during chronic dosing. These results strongly suggest possible drug accumulation. No differences in pharmacokinetic parameters were noted between evaluations at week 6 or week 12. Changes in pharmacodynamic response of glucose, insulin, and C-peptide to chronic glyburide therapy were observed. Glyburide therapy significantly reduced plasma glucose levels at weeks 6 and 12 (percent changes in AUC0-->4. glucose from baseline: week 0, -3 +/- 11%; week 6, -29 +/- 13%; and week 12, -26 +/- 19%). Pancreatic insulin secretion was acutely enhanced and maintained during long-term therapy. Responsiveness to therapy as assessed by the ratio of AUC0-->4.glucose:AUC0-->4.C-peptide was significantly improved at all weeks compared with baseline. No pharmacodynamic response differences were observed between the week 6 and the week 12 evaluations. CONCLUSIONS--This study demonstrates that significant differences in glyburide pharmacokinetics and pharmacodynamics exist between single-dose and steady-state conditions. These differences support the need for careful dosage titration of glyburide to achieve a desired therapeutic response in patients with type II diabetes.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				T. R. Moore Glyburide for the Treatment of Gestational Diabetes: A critical appraisal Diabetes Care, July 1, 2007; 30(Supplement_2): S209 - S213. [Full Text] [PDF]

				K. Maedler, R. D. Carr, D. Bosco, R. A. Zuellig, T. Berney, and M. Y. Donath Sulfonylurea Induced {beta}-Cell Apoptosis in Cultured Human Islets J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 501 - 506. [Abstract] [Full Text] [PDF]