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Diabetes Care, Vol 17, Issue 11 1345-1347, Copyright © 1994 by American Diabetes Association

ARTICLES

Cholesterol absorption and cholesterol and bile acid synthesis in two brothers with IDDM and diarrhea

H Gylling and TA Miettinen
Second Department of Medicine, University of Helsinki, Finland.

OBJECTIVE--To determine the best possible treatment for two brothers who had IDDM and bile acid malabsorption-associated disabling diarrhea that was resistant to cholestyramine, antibiotics, clonidine, loperamide, or anticholinergic drugs. RESEARCH DESIGN AND METHODS--Our study paired these two brothers with control subjects. Serum noncholesterol sterols and fecal elimination of cholesterol and plant sterols were quantitated by gas-liquid chromatography. RESULTS--Fecal losses of bile acids exceeded four to six times the control values, and cholesterol synthesis was increased two to three times. Cholesterol absorption efficiency and serum cholesterol concentrations were, respectively, within the high and low control range. CONCLUSIONS--Bile acid malabsorption might have resulted from deranged intestinal motility, possibly contributed by gastrointestinal neuropathy, and some genetic factor.
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This article has been cited by other articles:


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H. Gylling, J. A. Tuominen, V. A. Koivisto, and T. A. Miettinen
Cholesterol Metabolism in Type 1 Diabetes
Diabetes, September 1, 2004; 53(9): 2217 - 2222.
[Abstract] [Full Text] [PDF]

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T. A. Miettinen, H. Gylling, J. Tuominen, P. Simonen, and V. Koivisto
Low Synthesis and High Absorption of Cholesterol Characterize Type 1 Diabetes
Diabetes Care, January 1, 2004; 27(1): 53 - 58.
[Abstract] [Full Text] [PDF]


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Copyright © 1994 by the American Diabetes Association.