Diabetes Care, Vol 17, Issue 8 906-908, Copyright © 1994 by American Diabetes Association

ARTICLES

Remission of proteinuria following correction of hyperlipidemia in NIDDM patients with nondiabetic glomerulopathy

D Dubois, P Chanson, J Timsit, D Chauveau, D Nochy, PJ Guillausseau and J Lubetzki
Service de Medecine Interne, Hopital Lariboisiere, Paris, France.

OBJECTIVE--Animal studies suggest that hyperlipidemia may play a direct role in glomerular damage. In patients with non-insulin-dependent diabetes mellitus (NIDDM), dyslipidemia occurs early in the course of nephropathy and may be involved in the progression of renal disease. CASES--We report on two young NIDDM patients with marked hyperlipidemia and proteinuria, in whom renal biopsy demonstrated nondiabetic glomerulopathy. In both cases, the decrease in blood lipid levels was associated with a major decrease in proteinuria. Episodes of hyperlipidemia were associated with a resumption of heavy proteinuria in one patient with serum triglyceride levels and proteinuria being closely correlated. CONCLUSIONS--These two cases suggest that hyperlipidemia has an important role in the pathogenesis of glomerular disease.
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