Diabetes Care, Vol 18, Issue 5 618-624, Copyright © 1995 by American Diabetes Association

ARTICLES

Vessel wall properties of large arteries in uncomplicated IDDM

MJ Kool, J Lambert, CD Stehouwer, AP Hoeks, HA Struijker Boudier and LM Van Bortel
Department of Pharmacology, University of Limburg, Maastricht, The Netherlands.

OBJECTIVE--Patients with insulin-dependent diabetes mellitus (IDDM) are at high risk for cardiovascular disease. Arterial distensibility and compliance are vessel wall properties of large arteries. Altered large artery wall properties can be an early feature of vascular dysfunction. This study investigates vessel wall properties in 30 patients with uncomplicated IDDM and 30 matched healthy control subjects. RESEARCH DESIGN AND METHODS--Vessel wall properties of the elastic common carotid (CCA) and the muscular femoral (FA) and brachial arteries (BA) were measured with a vessel wall movement detector system. Blood pressure and heart rate were recorded simultaneously with a semiautomated device. Aortic pulse wave velocity was estimated from the carotido-femoral transit time. RESULTS--Blood pressure (IDDM patients: 118 +/- 10/69 +/- 5 mmHg), pulse pressure (IDDM patients: 49 +/- 8 mmHg), and heart rate (IDDM patients: 65 +/- 9 beats/min) were similar in IDDM patients and control subjects. No statistically significant changes between IDDM patients and control subjects were found for diameter, distensibility, and compliance of the elastic CCA and the muscular BA. Distensibility (IDDM patients: 16.9 +/- 6.4 10(-3)/kPa; control subjects: 22.4 +/- 11.8 10(-3)/kPa) of the muscular FA was decreased in IDDM (P < 0.05). However, FA compliance (IDDM patients: 0.80 +/- 0.23 mm2/kPa; control subjects: 0.94 +/- 0.41 mm2/kPa) and FA diameter (IDDM patients: 7.87 +/- 1.10 mm; control subjects: 7.57 +/- 1.11 mm) did not differ statistically between IDDM patients and control subjects. Aortic pulse wave velocity was the same in IDDM patients and control subjects (IDDM patients: 5.1 +/- 0.6 m/s). No relation was found between vessel wall properties and duration of disease, actual glucose level, and HbA1c for all three arteries (CCA, BA, and FA). But the groups might have been too small to draw conclusions. CONCLUSIONS--The results of the present study show that in this group of patients with uncomplicated IDDM, vessel wall properties of elastic and muscular large arteries were not obviously reduced when compared with healthy control subjects. However, distensibility of the FA was lower in IDDM patients. Early atherosclerotic changes in IDDM frequently occur at this site. A difference related to the duration of diabetes could not be excluded.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J.-C. Philips, M. Marchand, and A. J. Scheen Squatting Amplifies Pulse Pressure Increase With Disease Duration in Patients With Type 1 Diabetes Diabetes Care, February 1, 2008; 31(2): 322 - 324. [Abstract] [Full Text] [PDF]

				C. Giannattasio, M. Failla, A. Capra, E. Scanziani, M. Amigoni, L. Boffi, C. Whistock, P. Gamba, F. Paleari, and G. Mancia Increased Arterial Stiffness in Normoglycemic Normotensive Offspring of Type 2 Diabetic Parents Hypertension, February 1, 2008; 51(2): 182 - 187. [Abstract] [Full Text] [PDF]

				A. J. Sommerfield, I. B. Wilkinson, D. J. Webb, and B. M. Frier Vessel wall stiffness in type 1 diabetes and the central hemodynamic effects of acute hypoglycemia Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1274 - E1279. [Abstract] [Full Text] [PDF]

				A. Bilici, M. S. Ulgen, H. Nazaroglu, O. Ozturk, F. Ekici, C. Akgul, and B. Alan The Effect of ACE Gene Polymorphisms on Doppler Blood Flow Parameters of Carotid and Brachial Arteries in Patients With Myocardial Infarction Angiology, January 1, 2007; 57(6): 681 - 685. [Abstract] [PDF]

				M. E. Safar, S. Czernichow, and J. Blacher Obesity, Arterial Stiffness, and Cardiovascular Risk J. Am. Soc. Nephrol., April 1, 2006; 17(4_suppl_2): S109 - S111. [Abstract] [Full Text] [PDF]

				R. S. Reneman, J. M. Meinders, and A. P.G. Hoeks Non-invasive ultrasound in arterial wall dynamics in humans: what have we learned and what remains to be solved Eur. Heart J., May 2, 2005; 26(10): 960 - 966. [Abstract] [Full Text] [PDF]

				A. Tajaddini, D. L. Kilpatrick, P. Schoenhagen, E. M. Tuzcu, M. Lieber, and D. G. Vince Impact of age and hyperglycemia on the mechanical behavior of intact human coronary arteries: an ex vivo intravascular ultrasound study Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H250 - H255. [Abstract] [Full Text] [PDF]

				S. Alan, M. S. Ulgen, S. Akdeniz, B. Alan, and N. Toprak Intima-Media Thickness and Arterial Distensibility in Behcet's Disease Angiology, July 1, 2004; 55(4): 413 - 419. [Abstract] [PDF]

				C. Giannattasio, A. Vincenti, M. Failla, A. Capra, A. Ciro, S. De Ceglia, G. Gentile, R. Brambilla, and G. Mancia Effects of Heart Rate Changes on Arterial Distensibility in Humans Hypertension, September 1, 2003; 42(3): 253 - 256. [Abstract] [Full Text] [PDF]

				S. Alan, M. S. Ulgen, O. Ozturk, B. Alan, L. Ozdemir, and N. Toprak Relation Between Coronary Artery Disease, Risk Factors and Intima-Media Thickness of Carotid Artery, Arterial Distensibility, and Stiffness Index Angiology, May 1, 2003; 54(3): 261 - 267. [Abstract] [PDF]

				J. S. Romney and R. Z. Lewanczuk Vascular Compliance Is Reduced in the Early Stages of Type 1 Diabetes Diabetes Care, December 1, 2001; 24(12): 2102 - 2106. [Abstract] [Full Text] [PDF]

				J. Westerbacka, A. Uosukainen, S. Makimattila, A. Schlenzka, and H. Yki-Jarvinen Insulin-Induced Decrease in Large Artery Stiffness Is Impaired in Uncomplicated Type 1 Diabetes Mellitus Hypertension, May 1, 2000; 35(5): 1043 - 1048. [Abstract] [Full Text] [PDF]

				K. L. Berry, R. A. P. Skyrme-Jones, J. D. Cameron, R. C. O'Brien, and I. T. Meredith Systemic arterial compliance is reduced in young patients with IDDM Am J Physiol Heart Circ Physiol, June 1, 1999; 276(6): H1839 - H1845. [Abstract] [Full Text] [PDF]

				J. Lambert, M. van den Berg, M. Steyn, J. A. Rauwerda, A. J.M. Donker, and C. D.A. Stehouwer Familial hyperhomocysteinaemia and endothelium-dependent vasodilatation and arterial distensibility of large arteries Cardiovasc Res, June 1, 1999; 42(3): 743 - 751. [Abstract] [Full Text] [PDF]

				F. R. L. Crijns, B. H. R. Wolffenbuttel, J. G. R. de Mey, and H. A. J. S. Boudier Mechanical properties of mesenteric arteries in diabetic rats: consequences of outward remodeling Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1672 - H1677. [Abstract] [Full Text] [PDF]

				J. Lambert, R. Pijpers, F. J. van Ittersum, E. F.I. Comans, M. Aarsen, E. J. Pieper, A. J.M. Donker, and C. D.A. Stehouwer Sodium, Blood Pressure, and Arterial Distensibility in Insulin-Dependent Diabetes Mellitus Hypertension, November 1, 1997; 30(5): 1162 - 1168. [Abstract] [Full Text]

				J. Lambert, M. Aarsen, A. J.M. Donker, and C. D.A. Stehouwer Endothelium-Dependent and -Independent Vasodilation of Large Arteries in Normoalbuminuric Insulin-Dependent Diabetes Mellitus Arterioscler. Thromb. Vasc. Biol., May 1, 1996; 16(5): 705 - 711. [Abstract] [Full Text]

				L. M. Van Bortel, M. J. Kool, and H. A. Struijker Boudier Effects of Antihypertensive Agents on Local Arterial Distensibility and Compliance Hypertension, September 1, 1995; 26(3): 531 - 534. [Abstract] [Full Text]