Diabetes Care, Vol 20, Issue 1 77-80, Copyright © 1997 by American Diabetes Association

ARTICLES

The effect of prepubertal diabetes duration on diabetes. Microvascular complications in early and late adolescence

KC Donaghue, AT Fung, S Hing, J Fairchild, J King, A Chan, NJ Howard and M Silink
Ray Williams Institute of Paediatric Endocrinology, Diabetes and Metabolism, Royal Alexandra Hospital for Children, Westmead, Australia. kimd@mail.kids.usyd.edu.au

OBJECTIVE: To define the significance of prepubertal diabetes duration in the development of diabetic microvascular complications in adolescents. RESEARCH DESIGN AND METHODS: Study A compares complications in 38 prepubertal (PreP) and 140 pubertal (Pub) subjects of the same age (10-14 years) and diabetes duration (3-12 years) to determine if the absence of puberty itself confers a lower risk of complications. Study B examines the importance of prepubertal and pubertal diabetes duration in 193 older adolescents (ages 15-22 years) with prepubertal onset of diabetes. Retinopathy status was assessed using stereoscopic fundus photography of seven fields per eye. Albumin excretion rate (AER) was assessed by three consecutive overnight urine collections, using a polyclonal radioimmunoassay. RESULTS: In study A, there were no significant differences between the PreP and Pub groups for retinopathy (27 vs. 29%, P = 0.8) or differences in elevated AER (17 vs. 31%, P = 0.1). In study B, longer prepubertal diabetes duration improved the prediction for retinopathy over postpubertal duration alone (P < 0.0005). No relationship with duration was found for elevated AER (> 7.5, > 15, and > 30 micrograms/min). CONCLUSIONS: Prepubertal subjects with diabetes did not have less retinopathy or elevated albumin excretion compared with pubertal subjects of the same age. Prepubertal diabetes duration is significantly related to the presence of retinopathy in adolescents.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				N. Cheung, K. C. Donaghue, G. Liew, S. L. Rogers, J. J. Wang, S.-W. Lim, A. J. Jenkins, W. Hsu, M. L. Lee, and T. Y. Wong Quantitative Assessment of Early Diabetic Retinopathy Using Fractal Analysis Diabetes Care, January 1, 2009; 32(1): 106 - 110. [Abstract] [Full Text] [PDF]

				N. Cheung, S. L. Rogers, K. C. Donaghue, A. J. Jenkins, G. Tikellis, and T. Y. Wong Retinal Arteriolar Dilation Predicts Retinopathy in Adolescents With Type 1 Diabetes Diabetes Care, September 1, 2008; 31(9): 1842 - 1846. [Abstract] [Full Text] [PDF]

				M. C. Monti, J. T. Lonsdale, C. Montomoli, R. Montross, E. Schlag, and D. A. Greenberg Familial Risk Factors for Microvascular Complications and Differential Male-Female Risk in a Large Cohort of American Families with Type 1 Diabetes J. Clin. Endocrinol. Metab., December 1, 2007; 92(12): 4650 - 4655. [Abstract] [Full Text] [PDF]

				E. S. Majaliwa, E. Munubhi, K. Ramaiya, R. Mpembeni, A. Sanyiwa, A. Mohn, and F. Chiarelli Survey on Acute and Chronic Complications in Children and Adolescents With Type 1 Diabetes at Muhimbili National Hospital in Dar es Salaam, Tanzania Diabetes Care, September 1, 2007; 30(9): 2187 - 2192. [Abstract] [Full Text] [PDF]

				A. Morimoto, R. Nishimura, T. Matsudaira, H. Sano, N. Tajima, and for the Diabetes Epidemiology Research Internation Is Pubertal Onset a Risk Factor for Blindness and Renal Replacement Therapy in Childhood-Onset Type 1 Diabetes in Japan? Diabetes Care, September 1, 2007; 30(9): 2338 - 2340. [Full Text] [PDF]

				D. Cody Infant and toddler diabetes Arch. Dis. Child., August 1, 2007; 92(8): 716 - 719. [Full Text] [PDF]

				K. Yates, A. Hasnat Milton, K. Dear, and G. Ambler Continuous Glucose Monitoring-Guided Insulin Adjustment in Children and Adolescents on Near-Physiological Insulin Regimens: A randomized controlled trial Diabetes Care, July 1, 2006; 29(7): 1512 - 1517. [Abstract] [Full Text] [PDF]

				T. Berhe, D. Postellon, B. Wilson, and R. Stone Feasibility and safety of insulin pump therapy in children aged 2 to 7 years with type 1 diabetes: a retrospective study. Pediatrics, June 1, 2006; 117(6): 2132 - 2137. [Abstract] [Full Text] [PDF]

				M. Svensson, L. Nystrom, S. Schon, G. Dahlquist, and on behalf of the Swedish Childhood Diabetes Study Age at Onset of Childhood-Onset Type 1 Diabetes and the Development of End-Stage Renal Disease: A nationwide population-based study. Diabetes Care, March 1, 2006; 29(3): 538 - 542. [Abstract] [Full Text] [PDF]

				S. J. Glastras, M. E. Craig, C. F. Verge, A. K. Chan, J. M. Cusumano, and K. C. Donaghue The Role of Autoimmunity at Diagnosis of Type 1 Diabetes in the Development of Thyroid and Celiac Disease and Microvascular Complications Diabetes Care, September 1, 2005; 28(9): 2170 - 2175. [Abstract] [Full Text] [PDF]

				G. T. Lueder, J. Silverstein, and and Section on Ophthalmology and Section on Endocr Screening for Retinopathy in the Pediatric Patient With Type 1 Diabetes Mellitus Pediatrics, July 1, 2005; 116(1): 270 - 273. [Abstract] [Full Text] [PDF]

				J. Silverstein, G. Klingensmith, K. Copeland, L. Plotnick, F. Kaufman, L. Laffel, L. Deeb, M. Grey, B. Anderson, L. A. Holzmeister, et al. Care of Children and Adolescents With Type 1 Diabetes: A statement of the American Diabetes Association Diabetes Care, January 1, 2005; 28(1): 186 - 212. [Full Text] [PDF]

				V. Harjutsalo, S. Katoh, C. Sarti, N. Tajima, and J. Tuomilehto Population-Based Assessment of Familial Clustering of Diabetic Nephropathy in Type 1 Diabetes Diabetes, September 1, 2004; 53(9): 2449 - 2454. [Abstract] [Full Text] [PDF]

				M. Svensson, J. W. Eriksson, and G. Dahlquist Early Glycemic Control, Age at Onset, and Development of Microvascular Complications in Childhood-Onset Type 1 Diabetes: A population-based study in northern Sweden Diabetes Care, April 1, 2004; 27(4): 955 - 962. [Abstract] [Full Text] [PDF]

				K. N. Drummond, M. S. Kramer, S. Suissa, C. Levy-Marchal, S. Dell'Aniello, A. Sinaiko, and M. Mauer Effects of Duration and Age at Onset of Type 1 Diabetes on Preclinical Manifestations of Nephropathy Diabetes, July 1, 2003; 52(7): 1818 - 1824. [Abstract] [Full Text] [PDF]

				K. C. Donaghue, J. M. Fairchild, M. E. Craig, A. K. Chan, S. Hing, L. R. Cutler, N. J. Howard, and M. Silink Do All Prepubertal Years of Diabetes Duration Contribute Equally to Diabetes Complications? Diabetes Care, April 1, 2003; 26(4): 1224 - 1229. [Abstract] [Full Text] [PDF]

				M. J. Franz, J. P. Bantle, C. A. Beebe, J. D. Brunzell, J.-L. Chiasson, A. Garg, L. A. Holzmeister, B. Hoogwerf, E. Mayer-Davis, A. D. Mooradian, et al. Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications Diabetes Care, January 1, 2002; 25(1): 148 - 198. [Full Text] [PDF]

				J P H Shield and J D Baum Advances in childhood onset diabetes Arch. Dis. Child., April 1, 1998; 78(4): 391 - 394. [Full Text]

				Sections on Endocrinology and Ophthalmology Screening for Retinopathy in the Pediatric Patient With Type 1 Diabetes Mellitus Pediatrics, February 1, 1998; 101(2): 313 - 314. [Full Text] [PDF]