Diabetes Care, Vol 20, Issue 11 1683-1687, Copyright © 1997 by American Diabetes Association
U.K. Prospective Diabetes Study 27. Plasma lipids and lipoproteins at diagnosis of NIDDM by age and sex
OBJECTIVE: To compare fasting plasma lipids and lipoproteins in male and
female patients at diagnosis of NIDDM and to examine age and sex
differences in lipid concentrations. RESEARCH DESIGN AND METHODS:
Cross-sectional study of fasting plasma total cholesterol, LDL cholesterol,
HDL cholesterol, and triglyceride in 2,139 male and 1,574 female white
patients, aged 25-65 years, at diagnosis of NIDDM. RESULTS: At diagnosis of
NIDDM, the mean age +/- SD for men was 52 +/- 9 and 53 +/- 9 years for
women; BMI was 28.3 +/- 4.9 and 30.8 +/- 6.7 kg/m2, and fasting plasma
glucose was 11.6 +/- 3.6 and 12.4 +/- 3.8 mmol/l, respectively. The mean
total and LDL cholesterol were higher in female than in male NIDDM
patients, 5.8 +/- 1.2 vs. 5.5 +/- 1.1 and 3.9 +/- 1.1 vs. 3.6 +/- 1.0
mmol/l (both P < 0.001), respectively, while triglyceride levels were
similar: geometric mean (1 SD interval) for men and women was 1.8 (1.1-3.1)
vs. 1.8 (1.1-2.9) mmol/l. HDL cholesterol was higher in female than in male
NIDDM patients, 1.09 +/- 0.2 vs. 1.01 +/- 0.24 mmol/l (P < 0.001); the
sex differential for HDL cholesterol was 7% in NIDDM patients compared with
22% in the general population. Data analysis by 5-year age bands showed a
significant trend toward lower total cholesterol and triglyceride and
higher HDL cholesterol in men diagnosed above the age of 50 years. In
female NIDDM patients, lipid concentrations increased with age of diagnosis
but reached a plateau above the age of 50 years. CONCLUSIONS: The effect of
NIDDM, observed at diagnosis, on plasma lipid and lipoprotein levels is
more pronounced in women than in men. This may explain in part why the
cardiovascular risk is proportionally higher in female patients.
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