Diabetes Care, Vol 20, Issue 3 424-425, Copyright © 1997 by American Diabetes Association

ARTICLES

Activated protein C resistance in type I diabetes

G Gruden, C Olivetti, P Cavallo-Perin, M Bazzan, S Stella, G Tamponi and G Pagano
Department of Internal Medicine, University of Turin, Italy.

OBJECTIVE: To compare activated protein C (aPC) sensitivity in 37 type I diabetic patients and 33 healthy control subjects. RESEARCH DESIGN AND METHODS: In this study, 37 type I diabetic patients and 33 healthy control subjects without personal or familial history of venous thrombosis and coagulation disorders, infections, intercurrent conditions, serum lupus anticoagulant, clinical cardiovascular complications, or drugs were examined. RESULTS: The aPC ratio (aPTT [activated partial thromboplastin time] with and without aPC) was significantly lower in the type I diabetic patients than in the control subjects (P = 0.005). CONCLUSIONS: These results suggest that the final steps of the protein C/S inhibiting system could be abnormal in type I diabetes.
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