Diabetes Care, Vol 20, Issue 7 1159-1161, Copyright © 1997 by American Diabetes Association

ARTICLES

Clinical characteristics of Japanese men with glucokinase gene beta-cell promoter variant

K Yamada, X Yuan, S Ishiyama, F Ichikawa, KI Koyama, A Koyanagi, W Koyama and K Nonaka
Division of Endocrinology and Metabolism, Kurume University School of Medicine, Asahimachi, Japan.

OBJECTIVE: To study the association between a variant at the position of -30 of beta-cell-specific promoter of the glucokinase gene and glucose tolerance in the Japanese general population and to assess the clinical characteristics of subjects with the variant. RESEARCH DESIGN AND METHODS: The genotype of 657 Japanese men aged 51.0 +/- 8.8 years (mean +/- SD) was analyzed by an allele-specific assay using polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The variant allele frequency was 0.188 in subjects with normal glucose tolerance, 0.211 in subjects with impaired glucose tolerance, and 0.176 in diabetic subjects. In subjects with fasting plasma glucose levels <140 mg/dl, homozygous subjects for the promoter variant had significantly higher plasma glucose levels 60 min after oral glucose administration when compared with subjects without the variant allele. A cross-sectional analysis showed age-related elevation of basal glucose levels only in subjects without the promoter variant. Individuals heterozygous for the variant had significantly lower levels of HDL cholesterol than normal subjects. HDL cholesterol values were lower in homozygous people than in normal and heterozygous subjects, although the differences were not statistically significant. CONCLUSIONS: The beta-cell promoter variant in homozygous state was associated with impaired glucose tolerance, but not with diabetes, and low HDL cholesterol levels in Japanese men. It is unlikely that the glucose intolerance associated with the promoter variant is progressive with age.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				W. Winckler, M. N. Weedon, R. R. Graham, S. A. McCarroll, S. Purcell, P. Almgren, T. Tuomi, D. Gaudet, K. B. Bostrom, M. Walker, et al. Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes Diabetes, March 1, 2007; 56(3): 685 - 693. [Abstract] [Full Text] [PDF]

				J.-W. Jeong, I. Kwak, K. Y. Lee, L. D. White, X.-P. Wang, F. C. Brunicardi, B. W. O'Malley, and F. J. DeMayo The Genomic Analysis of the Impact of Steroid Receptor Coactivators Ablation on Hepatic Metabolism Mol. Endocrinol., May 1, 2006; 20(5): 1138 - 1152. [Abstract] [Full Text] [PDF]

				C. S. Rose, J. Ek, S. A. Urhammer, C. Glumer, K. Borch-Johnsen, T. Jorgensen, O. Pedersen, and T. Hansen A -30G>A Polymorphism of the {beta}-Cell-Specific Glucokinase Promoter Associates With Hyperglycemia in the General Population of Whites Diabetes, October 1, 2005; 54(10): 3026 - 3031. [Abstract] [Full Text] [PDF]

				O. Laukkanen, J. Lindstrom, J. Eriksson, T. T. Valle, H. Hamalainen, P. Ilanne-Parikka, S. Keinanen-Kiukaanniemi, J. Tuomilehto, M. Uusitupa, and M. Laakso Polymorphisms in the SLC2A2 (GLUT2) Gene Are Associated With the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes: The Finnish Diabetes Prevention Study Diabetes, July 1, 2005; 54(7): 2256 - 2260. [Abstract] [Full Text] [PDF]

				M. N. Weedon, T. M. Frayling, B. Shields, B. Knight, T. Turner, B. S. Metcalf, L. Voss, T. J. Wilkin, A. McCarthy, Y. Ben-Shlomo, et al. Genetic Regulation of Birth Weight and Fasting Glucose by a Common Polymorphism in the Islet Cell Promoter of the Glucokinase Gene Diabetes, February 1, 2005; 54(2): 576 - 581. [Abstract] [Full Text] [PDF]

				W. Marz, M. Nauck, M. M. Hoffmann, D. Nagel, B. O. Boehm, W. Koenig, D. Rothenbacher, and B. R. Winkelmann G(-30)A Polymorphism in the Pancreatic Promoter of the Glucokinase Gene Associated With Angiographic Coronary Artery Disease and Type 2 Diabetes Mellitus Circulation, June 15, 2004; 109(23): 2844 - 2849. [Abstract] [Full Text] [PDF]