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Diabetes Care, Vol 22, Issue 6 920-924, Copyright © 1999 by American Diabetes Association
Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. The Funagata Diabetes Study
M Tominaga, H Eguchi, H Manaka, K Igarashi, T Kato and A Sekikawa
Department of Laboratory Medicine, Yamagata University School of Medicine, Japan. mtominag@med.id.yamagata-u.ac.jp
OBJECTIVE: To determine whether the new category of impaired fasting
glucose (IFG) recently proposed by the Expert Committee of the American
Diabetes Association is a risk factor for cardiovascular disease. RESEARCH
DESIGN AND METHODS: Death certificates and residence transfer documents
from the cohort population consisting of participants of the diabetes
prevalence study in Funagata, Yamagata prefecture, Japan, 1990-1992, were
analyzed up through the end of 1996. First, the cohort population was
classified into three groups: normal glucose tolerance (NGT) (n = 2,016),
impaired glucose tolerance (IGT) (n = 382), and diabetic (n = 253). Then
the same population was reclassified into normal fasting glucose (NFG),
IFG, and diabetic. The cumulative survival rates among the groups were
compared using the classical life-table method, and age-adjusted analyses,
the person-year method, and Cox's proportional hazard model were adopted.
RESULTS: At the end of seven observed years, the cumulative survival rates
from cardiovascular disease of IGT and diabetes were 0.962 and 0.954,
respectively, both significantly lower than that of NGT (0.988). The Cox's
proportional hazard model analysis showed that the hazard ratio of IGT to
NGT on death from cardiovascular disease was 2.219 (95% CI 1.076-4.577).
However, the cumulative survival rate of IFG from cardiovascular disease
was 0.977, not significantly lower than that of NFG (0.985). The Cox's
hazard ratio of IFG to NFG on death from cardiovascular disease was 1.136
(0.345-3.734), which was not significant either. CONCLUSIONS: IGT was a
risk factor for cardiovascular disease, but IFG was not.

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