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Diabetes Care 24:280-283, 2001
© 2001 by the American Diabetes Association, Inc.

Epidemiology/Health Services/Psychosocial Research
Original Article

African-American Women Have Higher Initial HbAlc Levels in Diabetic Pregnancy

William L. Holcomb, Jr., MD, Dorothea J. Mostello, MD and Gustavo F. Leguizamon, MD

From the St. Louis University School of Medicine (W.L.H., D.J.M), and the Washington University School of Medicine (G.F.L.), St. Louis, Missouri.

Address correspondence and reprint requests to William L. Holcomb Jr., MD, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, St. Louis University, 6420 Clayton Rd., St. Louis, MO 63117. E-mail: holcombw{at}slu.edu .

OBJECTIVE— African-American women with diabetes are at greater risk for poor glycemic control outside of pregnancy. We evaluated the effect of race on glycemic control in a racially mixed population of women with diabetes entering prenatal care.

RESEARCH DESIGN AND METHODS— HbAlc levels along with demographic data were collected at the first prenatal visit from a group of 234 women with preexisting diabetes. We applied logistic multivariate analysis to identify factors associated with HbAlc levels above the median for the group.

RESULTS— The median HbAlc level for the group was 8%. HbAlc levels were 8.7 ± 2.0% in African-Americans and 7.7 ± 1.5% in Caucasians (P < 0.001). African-American racial designation was significantly and independently associated with high HbAlc when controlled for maternal age, parity, White classification, diabetes type, education, marital status, obesity, insurance type, and first trimester entry into care. The effect of race was confined to the nonobese patients, for whom the adjusted odds ratio for African-American race as a predictor of high HbAlc was 8.15 with a 95% CI of 2.41-27.58 (P = 0.001).

CONCLUSIONS— We found a clear racial disparity in glycemic control among women entering prenatal care with preexisting diabetes. This study demonstrates that there generally is need for better glycemic control among reproductive-age women with diabetes, but especially among those who are African-American.


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Copyright © 2001 by the American Diabetes Association.