Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schmidt, M. I.
Right arrow Articles by Yamashita, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schmidt, M. I.
Right arrow Articles by Yamashita, T.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Diabetes Care 24:1151-1155, 2001
© 2001 by the American Diabetes Association, Inc.

Epidemiology/Health Services/Psychosocial Research
Original Article

Gestational Diabetes Mellitus Diagnosed With a 2-h 75-g Oral Glucose Tolerance Test and Adverse Pregnancy Outcomes

Maria I. Schmidt, MD, PHD1, Bruce B. Duncan, MD, PHD1, Angela J. Reichelt, MD, PHD2, Leandro Branchtein, MD, PHD2, Maria C. Matos, MD, PHD2, Adriana Costa e Forti, MD, PHD3, Ethel R. Spichler, MD, PHD4, Judith M.D.C. Pousada, MD, PHD5, Margareth M. Teixeira, MD, MS6, Tsuyoshi Yamashita, MD7 and For the Brazilian Gestational Diabetes Study Group

1 Department of Social Medicine, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre
2 Postgraduate Program in Clinical Medicine, Federal University of Rio Grande do Sul, Porto Alegre
3 Department of Clinical Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará
4 Department of Obstetrics and Gynecology, Instituto Fernandes Figueira–Oswaldo Cruz Foundation, Rio de Janeiro
5 Department of Medicine, Medical School, Federal University of Bahia, Salvador, Bahia
6 Department of Medicine, Federal University of Amazonas, Manaus, Amazonas
7 Hospital dos Servidores Públicos do Estado de São Paulo, São Paulo, Brazil

OBJECTIVE—To evaluate American Diabetes Association (ADA) and World Health Organization (WHO) diagnostic criteria for gestational diabetes mellitus (GDM) against pregnancy outcomes.

RESEARCH DESIGN AND METHODS—This cohort study consecutively enrolled Brazilian adult women attending general prenatal clinics. All women were requested to undertake a standardized 2-h 75-g oral glucose tolerance test (OGTT) between their estimated 24th and 28th gestational weeks and were then followed to delivery. New ADA criteria for GDM require two plasma glucose values >=5.3 mmol/l (fasting), >=10 mmol/l (1 h), and >=8.6 mmol/l (2 h). WHO criteria require a plasma glucose >=7.0 mmol/l (fasting) or >=7.8 mmol/l (2 h). Individuals with hyperglycemia indicative of diabetes outside of pregnancy were excluded.

RESULTS—Among the 4,977 women studied, 2.4% (95% CI 2.0–2.9) presented with GDM by ADA criteria and 7.2% (6.5–7.9) by WHO criteria. After adjustment for the effects of age, obesity, and other risk factors, GDM by ADA criteria predicted an increased risk of macrosomia (RR 1.29, 95% CI 0.73–2.18), preeclampsia (2.28, 1.22–4.16), and perinatal death (3.10, 1.42–6.47). Similarly, GDM by WHO criteria predicted increased risk for macrosomia (1.45, 1.06–1.95), preeclampsia (1.94, 1.22–3.03), and perinatal death (1.59, 0.86–2.90). Of women positive by WHO criteria, 260 (73%) were negative by ADA criteria. Conversely, 22 (18%) women positive by ADA criteria were negative by WHO criteria.

CONCLUSIONS—GDM based on a 2-h 75-g OGTT defined by either WHO or ADA criteria predicts adverse pregnancy outcomes.

Abbreviations: ADA, American Diabetes Association • GDM, gestational diabetes mellitus • OGTT, oral glucose tolerance test • RR, relative risk • WHO, World Health Organization


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Clin. Chem.Home page
G. Mello, P. Elena, A. Ognibene, R. Cioni, F. Tondi, P. Pezzati, M. Pratesi, G. Scarselli, and G. Messeri
Lack of Concordance between the 75-g and 100-g Glucose Load Tests for the Diagnosis of Gestational Diabetes Mellitus
Clin. Chem., September 1, 2006; 52(9): 1679 - 1684.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
E. Parretti, A. Lapolla, M. Dalfra, G. Pacini, A. Mari, R. Cioni, C. Marzari, G. Scarselli, and G. Mello
Preeclampsia in Lean Normotensive Normotolerant Pregnant Women Can Be Predicted by Simple Insulin Sensitivity Indexes
Hypertension, March 1, 2006; 47(3): 449 - 453.
[Abstract] [Full Text] [PDF]

Home page
 Clin. DiabetesHome page
G. D. Harris and R. D. White
Diabetes Management and Exercise in Pregnant Patients With Diabetes
Clin. Diabetes, October 1, 2005; 23(4): 165 - 168.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
I. A. Santos, R. Stein, S. C. Fuchs, B. B. Duncan, J. P. Ribeiro, L. R. Kroeff, M. T. Carballo, and M. I. Schmidt
Aerobic Exercise and Submaximal Functional Capacity in Overweight Pregnant Women: A Randomized Trial
Obstet. Gynecol., August 1, 2005; 106(2): 243 - 249.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
R. Shankar, N. Gude, F. Cullinane, S. Brennecke, A. W Purcell, and E. K Moses
An emerging role for comprehensive proteome analysis in human pregnancy research
Reproduction, June 1, 2005; 129(6): 685 - 696.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
S. H. Saydah, A. Chandra, and M. S. Eberhardt
Pregnancy Experience Among Women With and Without Gestational Diabetes in the U.S., 1995 National Survey of Family Growth
Diabetes Care, May 1, 2005; 28(5): 1035 - 1040.
[Abstract] [Full Text] [PDF]

Home page
 Clin. DiabetesHome page
T. L. Setji, A. J. Brown, and M. N. Feinglos
Gestational Diabetes Mellitus
Clin. Diabetes, January 1, 2005; 23(1): 17 - 24.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. Wolf, A. Shah, R. Jimenez-Kimble, J. Sauk, J. L. Ecker, and R. Thadhani
Differential Risk of Hypertensive Disorders of Pregnancy among Hispanic Women
J. Am. Soc. Nephrol., May 1, 2004; 15(5): 1330 - 1338.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
R. Thadhani, J. L. Ecker, W. P. Mutter, M. Wolf, K. V. Smirnakis, V. P. Sukhatme, R. J. Levine, and S. A. Karumanchi
Insulin Resistance and Alterations in Angiogenesis: Additive Insults That May Lead to Preeclampsia
Hypertension, May 1, 2004; 43(5): 988 - 992.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
N. W. Cheung and K. Byth
Population Health Significance of Gestational Diabetes
Diabetes Care, July 1, 2003; 26(7): 2005 - 2009.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Wolf, L. Sandler, K. Munoz, K. Hsu, J. L. Ecker, and R. Thadhani
First Trimester Insulin Resistance and Subsequent Preeclampsia: A Prospective Study
J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1563 - 1568.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
U. Dashora, V. Dashora, and L. Kennedy
Two-hour 75-g Oral Glucose Tolerance Test Early in Pregnancy Detects Most Cases of Gestational Diabetes
Diabetes Care, April 1, 2002; 25(4): 803 - 803.
[Full Text]

Home page
 Diabetes CareHome page
M. I. Schmidt, B. B. Duncan, and A. J. Reichelt
Response to Dashora et al.
Diabetes Care, April 1, 2002; 25(4): 804 - 804.
[Full Text]

Home page
 Diabetes CareHome page
D. J. Pettitt
The 75-g Oral Glucose Tolerance Test in Pregnancy
Diabetes Care, July 1, 2001; 24(7): 1129 - 1129.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2001 by the American Diabetes Association.