Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nichols, G. A.
Right arrow Articles by Brown, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nichols, G. A.
Right arrow Articles by Brown, J. B.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Diabetes Care 24:1614-1619, 2001
© 2001 by the American Diabetes Association, Inc.

Pathophysiology/Complications
Original Article

Congestive Heart Failure in Type 2 Diabetes

Prevalence, incidence, and risk factors

Gregory A. Nichols, PHD1, Teresa A. Hillier, MD, MS1, John R. Erbey, PHD2 and Jonathan B. Brown, PHD, MPP1

1 Kaiser Permanente Center for Health Research, Portland, Oregon, and
2 Schering-Plough Pharmaceuticals, Kenilworth, New Jersey

OBJECTIVE—To estimate the prevalence and incidence of congestive heart failure (CHF) in populations with and without type 2 diabetes and to identify risk factors for diabetes-associated CHF.

RESEARCH DESIGN AND METHODS—We searched the inpatient and outpatient electronic medical records of 9,591 individuals diagnosed with type 2 diabetes before 1 January 1997 and those of an age- and sex-matched control group without diabetes for a diagnosis of CHF. Among those without a baseline diagnosis of CHF, we searched forward for 30 months for incident cases of CHF. We constructed multiple logistic regression models to identify risk factors for both prevalent and incident CHF.

RESULTS—CHF was prevalent in 11.8% (n = 1,131) of diabetic subjects and 4.5% (n = 435) of control subjects at baseline. We observed incident cases of CHF in 7.7% of diabetic subjects free of CHF at baseline (650 of 8,460) and in 3.4% of control subjects (314 of 9,156). In diabetic subjects, age, diabetes duration, insulin use, ischemic heart disease, and elevated serum creatinine were independent risk factors for both prevalent and incident CHF. Better glycemic control at baseline, and improved glycemic and blood pressure control at follow-up predicted the development of CHF.

CONCLUSIONS—Despite controlling for age, duration of diabetes, presence of ischemic heart disease, and presence of hypertension, insulin use was associated with both prevalent and incident CHF. Why insulin use and better glycemic control both at baseline and follow-up independently predicted CHF deserves further study.

Abbreviations: CAD, coronary artery disease • CHF, congestive heart failure • FHS, Framingham Heart Study • OR, odds ratio • KPNW, Kaiser Permanente Northwest Division • UKPDS, U.K. Prospective Diabetes Study • VA CSDM, Veterans Affairs Cooperative Study in Type 2 Diabetes Mellitus


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
N. Cheung, J. J. Wang, S. L. Rogers, F. Brancati, R. Klein, A. R. Sharrett, T. Y. Wong, and for the ARIC (Atherosclerosis Risk In Communities)
Diabetic retinopathy and risk of heart failure.
J. Am. Coll. Cardiol., April 22, 2008; 51(16): 1573 - 1578.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
D. T Eurich, F. A McAlister, D. F Blackburn, S. R Majumdar, R. T Tsuyuki, J. Varney, and J. A Johnson
Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review
BMJ, September 8, 2007; 335(7618): 497 - 497.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Boudina and E. D. Abel
Diabetic Cardiomyopathy Revisited
Circulation, June 26, 2007; 115(25): 3213 - 3223.
[Abstract] [Full Text] [PDF]

Home page
 Am J Health Syst PharmHome page
M. C. Granberry, J. B. Hawkins, and A. M. Franks
Thiazolidinediones in patients with type 2 diabetes mellitus and heart failure
Am. J. Health Syst. Pharm., May 1, 2007; 64(9): 931 - 936.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
C.-H. Tseng
Exogenous Insulin Use and Hypertension in Adult Patients With Type 2 Diabetes Mellitus.
Arch Intern Med, June 12, 2006; 166(11): 1184 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
R. E. Gilbert, K. Connelly, D. J. Kelly, C. A. Pollock, and H. Krum
Heart Failure and Nephropathy: Catastrophic and Interrelated Complications of Diabetes
Clin. J. Am. Soc. Nephrol., March 1, 2006; 1(2): 193 - 208.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. Ronnback, B. Isomaa, J. Fagerudd, C. Forsblom, P.-H. Groop, T. Tuomi, L. Groop, and for the Botnia Study Group
Complex Relationship Between Blood Pressure and Mortality in Type 2 Diabetic Patients: A Follow-Up of the Botnia Study
Hypertension, February 1, 2006; 47(2): 168 - 173.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
D. T. Eurich, S. R. Majumdar, F. A. McAlister, R. T. Tsuyuki, and J. A. Johnson
Improved Clinical Outcomes Associated With Metformin in Patients With Diabetes and Heart Failure
Diabetes Care, October 1, 2005; 28(10): 2345 - 2351.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
F. A. Masoudi, C. P. Gross, Y. Wang, S. S. Rathore, E. P. Havranek, J. M. Foody, and H. M. Krumholz
Adoption of Spironolactone Therapy for Older Patients With Heart Failure and Left Ventricular Systolic Dysfunction in the United States, 1998-2001
Circulation, July 5, 2005; 112(1): 39 - 47.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
C. Nielson and T. Lange
Blood Glucose and Heart Failure in Nondiabetic Patients
Diabetes Care, March 1, 2005; 28(3): 607 - 611.
[Abstract] [Full Text] [PDF]

Home page
 British Journal of Diabetes & Vascular DiseaseHome page
L. Rodriguez-Manas, M. Castro, and J. Manzarbeitia
Review: Cardiovascular risk and diabetes in old people
The British Journal of Diabetes & Vascular Disease, January 1, 2005; 5(1): 7 - 11.
[Abstract] [PDF]

Home page
 Diabetes CareHome page
S. Maru, G. G. Koch, M. Stender, D. Clark, L. Gibowski, H. Petri, A. D. White, and R. J. Simpson Jr.
Antidiabetic Drugs and Heart Failure Risk in Patients With Type 2 Diabetes in the U.K. Primary Care Setting
Diabetes Care, January 1, 2005; 28(1): 20 - 26.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
G. A. Nichols, C. M. Gullion, C. E. Koro, S. A. Ephross, and J. B. Brown
The Incidence of Congestive Heart Failure in Type 2 Diabetes: An update
Diabetes Care, August 1, 2004; 27(8): 1879 - 1884.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
L. H. Young
Diastolic Function and Type 1 Diabetes
Diabetes Care, August 1, 2004; 27(8): 2081 - 2083.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. I. Barzilay, R. A. Kronmal, J. S. Gottdiener, N. L. Smith, G. L. Burke, R. Tracy, P. J. Savage, and M. Carlson
The association of fasting glucose levels with congestive heart failure in diabetic adults >=65 years: The Cardiovascular Health Study
J. Am. Coll. Cardiol., June 16, 2004; 43(12): 2236 - 2241.
[Abstract] [Full Text] [PDF]

Home page
 Clin. DiabetesHome page
D. S.H. Bell
Heart Failure: A Serious and Common Comorbidity of Diabetes
Clin. Diabetes, April 1, 2004; 22(2): 61 - 65.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
A. G. Bertoni, W. G. Hundley, M. W. Massing, D. E. Bonds, G. L. Burke, and D. C. Goff Jr.
Heart Failure Prevalence, Incidence, and Mortality in the Elderly With Diabetes
Diabetes Care, March 1, 2004; 27(3): 699 - 703.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
C. F. Schaars, P. Denig, W. N. Kasje, R. E. Stewart, B. H.R. Wolffenbuttel, and F. M. Haaijer-Ruskamp
Physician, Organizational, and Patient Factors Associated With Suboptimal Blood Pressure Management in Type 2 Diabetic Patients in Primary Care
Diabetes Care, January 1, 2004; 27(1): 123 - 128.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
R. W. Nesto, D. Bell, R. O. Bonow, V. Fonseca, S. M. Grundy, E. S. Horton, M. Le Winter, D. Porte, C. F. Semenkovich, S. Smith, et al.
Thiazolidinedione Use, Fluid Retention, and Congestive Heart Failure: A consensus statement from the American Heart Association and American Diabetes Association
Diabetes Care, January 1, 2004; 27(1): 256 - 263.
[Full Text] [PDF]

Home page
 CirculationHome page
R. W. Nesto, D. Bell, R. O. Bonow, V. Fonseca, S. M. Grundy, E. S. Horton, M. Le Winter, D. Porte, C. F. Semenkovich, S. Smith, et al.
Thiazolidinedione Use, Fluid Retention, and Congestive Heart Failure: A Consensus Statement From the American Heart Association and American Diabetes Association
Circulation, December 9, 2003; 108(23): 2941 - 2948.
[Full Text] [PDF]

Home page
 Diabetes CareHome page
T. E. Delea, J. S. Edelsberg, M. Hagiwara, G. Oster, and L. S. Phillips
Use of Thiazolidinediones and Risk of Heart Failure in People With Type 2 Diabetes: A retrospective cohort study
Diabetes Care, November 1, 2003; 26(11): 2983 - 2989.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
D. S.H. Bell
Heart Failure: The frequent, forgotten, and often fatal complication of diabetes
Diabetes Care, August 1, 2003; 26(8): 2433 - 2441.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
V. Epshteyn, K. Morrison, P. Krishnaswamy, R. Kazanegra, P. Clopton, S. Mudaliar, S. Edelman, R. Henry, and A. Maisel
Utility of B-Type Natriuretic Peptide (BNP) as a Screen for Left Ventricular Dysfunction in Patients With Diabetes
Diabetes Care, July 1, 2003; 26(7): 2081 - 2087.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
L. Vaur, P. Gueret, M. Lievre, S. Chabaud, and P. Passa
Development of Congestive Heart Failure in Type 2 Diabetic Patients With Microalbuminuria or Proteinuria: Observations from the DIABHYCAR (type 2 DIABetes, Hypertension, CArdiovascular Events and Ramipril) study
Diabetes Care, March 1, 2003; 26(3): 855 - 860.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
D. S. Silverberg, D. Wexler, M. Blum, J. Z. Tchebiner, D. Sheps, G. Keren, D. Schwartz, R. Baruch, T. Yachnin, M. Shaked, et al.
The effect of correction of anaemia in diabetics and non-diabetics with severe resistant congestive heart failure and chronic renal failure by subcutaneous erythropoietin and intravenous iron
Nephrol. Dial. Transplant., January 1, 2003; 18(1): 141 - 146.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
Z. T. Bloomgarden
Cardiovascular Disease and Diabetes
Diabetes Care, January 1, 2003; 26(1): 230 - 237.
[Full Text] [PDF]

Home page
 JAMAHome page
M. E. Molitch, W. E. Cayley, Jr, R. Rothman, M. Pignone, B. Bryant, R. Malone, and C. Horlen
Inappropriate Prescription for Metformin
JAMA, August 14, 2002; 288(6): 694 - 695.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2001 by the American Diabetes Association.