HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Perseghin, G. Articles by Luzi, L. Search for Related Content PubMed PubMed Citation Articles by Perseghin, G. Articles by Luzi, L. Social Bookmarking                What's this?

Fasting Blood Sample-Based Assessment of Insulin Sensitivity in Kidney-Pancreas-Transplanted Patients

¹ Nutrition/Metabolism, Istituto Scientifico H San Raffaele, Milan, Italy
² International Center for the Assessment of Nutritional Status, Università degli Studi di Milano, Milan, Italy

OBJECTIVE—To ascertain whether simple indexes of insulin sensitivity based on a fasting blood sample may be reliable measures of insulin sensitivity in combined kidney-pancreas- transplanted patients.

RESEARCH DESIGN AND METHODS—Estimates of insulin sensitivity based on fasting plasma glucose, insulin (homeostasis model assessment of insulin sensitivity [HOMA-IS], Quantitative Insulin Sensitivity Check Index [QUICKI]), and free fatty acid (revised QUICKI) concentrations were compared with insulin sensitivity as assessed with the gold standard technique (euglycemic-hyperinsulinemic clamp) in 22 patients who had undergone kidney-pancreas transplantation (KP-Tx) and 18 matched healthy subjects (NOR).

RESULTS—In KP-Tx patients, indexes based on the glucose-insulin product, HOMA-IS (r = 0.47, P = 0.03) and QUICKI (r = 0.47, P = 0.03), were shown to be reliable measures of insulin sensitivity. The introduction of fasting plasma free fatty acid concentration in the revised QUICKI (r = 0.76, P < 0.0001) considerably improved the power of prediction of the clamp-based measure of insulin sensitivity as observed in the healthy control subjects (r = 0.83, P < 0.0001).

CONCLUSIONS—This study shows that in KP-Tx patients, HOMA-IS and QUICKI are reliable measures of insulin sensitivity; the additional incorporation of fasting plasma free fatty acid concentration into the glucose-insulin product (revised QUICKI) resulted in a considerably more powerful index.

Abbreviations: CV, coefficient of variation • FFA, free fatty acid • GIR, glucose infusion rate • KP-Tx, kidney-pancreas transplantation • HOMA-IS, homeostasis model assessment of insulin sensitivity • HOMA-IR, homeostasis model assessment of insulin resistance • NOR, matched healthy subjects • QUICKI, Quantitative Insulin Sensitivity Check Index

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				P. Fiorina, A. Vergani, A. Petrelli, F. D'Addio, L. Monti, R. Abdi, E. Bosi, P. Maffi, and A. Secchi Metabolic and Immunological Features of the Failing Islet-Transplanted Patient Diabetes Care, March 1, 2008; 31(3): 436 - 438. [Abstract] [Full Text] [PDF]

				M. Stadler, C. Anderwald, T. Karer, A. Tura, T. Kastenbauer, M. Auinger, C. Bieglmayer, O. Wagner, F. Kronenberg, P. Nowotny, et al. Increased Plasma Amylin in Type 1 Diabetic Patients After Kidney and Pancreas Transplantation: A sign of impaired {beta}-cell function? Diabetes Care, May 1, 2006; 29(5): 1031 - 1038. [Abstract] [Full Text] [PDF]