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Prevalence of Insulin Resistance Syndrome in Southwestern France and Its Relationship With Inflammatory and Hemostatic Markers

¹ INSERM U558, Faculté de Médecine Purpan, Toulouse, France
² Service d’Angio-Hématologie Biologique et Moléculaire, Hôpital Lariboisière, Paris, France
³ Service de Diabétologie, Maladies Métaboliques et Nutrition, C.H.U. Rangueil, Toulouse, France

OBJECTIVE—To assess the prevalence and relationships of insulin resistance syndrome (IRS) with inflammatory and hemostatic markers in a representative sample of the population of Southwestern France aged 35–64 years.

RESEARCH DESIGN AND METHODS—In this cross-sectional study, data were collected from 597 men and 556 women and were assessed regarding BMI, blood pressure, total and HDL cholesterol levels, triglyceride level, glucose level, plasma insulin level, white blood cell count, fibrinogen level, factor VII level, von Willebrand factor, C-reactive protein level, soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule-1, and soluble CD₁₄. Insulin resistance was defined by homeostasis model assessment 3.8.

RESULTS—Prevalence of IRS was higher in men than in women (23 vs. 12%, respectively; P < 0.001) and increased with age in both sexes (9, 24, and 34% for age groups 35–44, 45–54, and 55–64 years, respectively, for men and 4, 10, and 21% for women). After adjusting for age, alcohol consumption, tobacco smoking, and also for menopause in women, subjects (men and women) with IRS had significantly higher white blood cell count, factor VII levels, coagulating factor VII levels, and C-reactive protein levels than the other subjects. In men, further increases in soluble intercellular adhesion molecule and soluble vascular cell adhesion molecule-1 were noted, whereas in women, the differences were borderline significant. Conversely, no differences were found in fibrinogen, von Willebrand factor, and soluble CD₁₄ in both sexes.

CONCLUSIONS—IRS is relatively common in residents of Southwestern France and is related to a deleterious increase in hemostatic and inflammatory parameters.

Abbreviations: CRP, C-reactive protein • DBP, diastolic blood pressure • FPG, fasting plasma glucose • FVIIa, activated factor VII • FVIIc, factor VII coagulant • HOMA, homeostasis model assessment • IFG, impaired fasting glucose • IRS, insulin resistance syndrome • SBP, systolic blood pressure • sCD₁₄, soluble CD₁₄ • sICAM, soluble intercellular adhesion molecule • sVCAM-1, soluble vascular cell adhesion molecule-1 • WHR, waist-to-hip ratio

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