Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by De Cosmo, S.
Right arrow Articles by Fioretto, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Cosmo, S.
Right arrow Articles by Fioretto, P.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Diabetes Care 26:2898-2902, 2003
© 2003 by the American Diabetes Association, Inc.

Pathophysiology/Complications
Original Article

PC-1 Amino Acid Variant Q121 Is Associated With a Lower Glomerular Filtration Rate in Type 2 Diabetic Patients With Abnormal Albumin Excretion Rates

Salvatore De Cosmo, MD1, Roberto Trevisan, MD2, Michele Dalla Vestra, MD3, Monica Vedovato, MD2, Alessandra Argiolas, PHD4, Anna Solini, MD5, Alois Saller, MD3, Francesco Damone, MD1, Antonio Tiengo, MD2, Vincenzo Trischitta, MD1,6 and Paola Fioretto, MD3

1 Unit of Endocrinology, Scientific Institute "Casa Sollievo della Sofferenza," San Giovanni Rotondo, Italy
2 Department of Clinical Medicine, University of Padova, Padova, Italy
3 Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
4 Scientific Institute CSS-Mendel, Rome, Italy
5 Department of Internal Medicine, University of Pisa, Pisa, Italy
6 Department of Clinical Science, University "La Sapienza," Rome, Italy

Address correspondence and reprint requests to Vincenzo Trischitta, MD, Unit of Endocrinology, Scientific Institute "Casa Sollievo della Sofferenza," 71013 San Giovanni Rotondo (FG), Italy. E-mail: vincenzo.trischitta{at}uniroma1.it

OBJECTIVE—To study the relationships between the PC-1 K121Q variant and diabetic nephropathy (DN) in patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS—A total of 125 patients with type 2 diabetes and abnormal albumin excretion rate (AER) (range 20–5,416 µg/min) were followed up for 4 years with repeated measurements of glomerular filtration rate (GFR). Genomic DNA was extracted from all patients, and the PC-1 K121Q polymorphism was determined by the PCR AvaII restriction enzyme. A subset of 64 patients underwent a percutaneous kidney biopsy at baseline, and glomerular structure was analyzed by electron microscopic morphometric analysis. At baseline, age (56 ± 8 vs. 59 ± 7 years), BMI (28.3 ± 4.3 vs. 28.6 ± 3.7 kg/m2), known duration of type 2 diabetes (11.1 ± 7 vs. 11.9 ± 8 years), and HbA1c (8.6 ± 1.8 vs. 8.4 ± 1.7%) were similar in K121K (KK, n = 87, 73 men/14 women) and XQ (35 K121Q + 3 Q121Q, n = 38, 27 men/11 women) patients. Baseline GFR was 96 ± 28 ml · min-1 · 1.73 m-2 and was related (P = 0.01–0.001) to age, known diabetes duration, and systolic blood pressure.

RESULTS—XQ patients had lower GFR (P < 0.05) than KK patients (88 ± 30 vs. 100 ± 26 ml · min-1 · 1.73 m-2); this difference persisted also after factoring in age and known diabetes duration. The rate of progression of DN was similar in KK and XQ patients: %{Delta}GFR was 4.1/year (median, range: 22.9–30.6) vs. 4.2/year (9.8–26.7). Morphometric parameters of diabetic glomerulopathy were similar in the two genotype groups.

CONCLUSIONS—Among patients with type 2 diabetes with abnormal AER, those carrying the Q PC-1 genotype have more severe DN but not a faster GFR decline than KK patients, thus suggesting faster DN development since diabetes diagnosis in XQ patients.

Abbreviations: AER, albumin excretion rate • DN, diabetic nephropathy • GFR, glomerular filtration rate • Vv(mes/glom), fractional volume of the glomerulus occupied by mesangium • Vv(MM/glom), fractional volume of the glomerulus occupied by mesangial matrix


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
S. D. Nath, V. S. Voruganti, N. H. Arar, F. Thameem, J. C. Lopez-Alvarenga, R. Bauer, J. Blangero, J. W. MacCluer, A. G. Comuzzie, and H. E. Abboud
Genome Scan for Determinants of Serum Uric Acid Variability
J. Am. Soc. Nephrol., December 1, 2007; 18(12): 3156 - 3163.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
D. J. Friedman, H. G. Rennke, E. Csizmadia, K. Enjyoji, and S. C. Robson
The Vascular Ectonucleotidase ENTPD1 Is a Novel Renoprotective Factor in Diabetic Nephropathy
Diabetes, September 1, 2007; 56(9): 2371 - 2379.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
S. De Cosmo, A. Marucci, E. Ciociola, R. Di Paola, L. Pucci, G. Penno, S. Del Prato, G. P. Piras, R. Trevisan, S. Giunti, et al.
Lack of evidence for the 1484insG variant at the 3'-UTR of the protein tyrosine phosphatase 1B (PTP1B) gene as a genetic determinant of diabetic nephropathy development in type 1 diabetic patients
Nephrol. Dial. Transplant., September 1, 2004; 19(9): 2419 - 2420.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2003 by the American Diabetes Association.