HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Snehalatha, C. Articles by Ramachandran, A. Search for Related Content PubMed PubMed Citation Articles by Snehalatha, C. Articles by Ramachandran, A. Social Bookmarking                What's this?

Plasma Adiponectin Is an Independent Predictor of Type 2 Diabetes in Asian Indians

¹ Diabetes Research Centre, M.V. Hospital for Diabetes, WHO Collaborating Centre for Research, Education & Training in Diabetes, Royapuram, Chennai, India
² Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center of San Antonio, San Antonio, Texas

Address correspondence and reprint requests to Prof. A. Ramachandran, Director, Diabetes Research Centre, M.V. Hospital for Diabetes & WHO Collaborating Centre for Research, Education & Training in Diabetes, 4 Main Rd., Royapuram, Chennai 600 013, India. E-mail: ramachandran{at}vsnl.com

OBJECTIVE—Adiponectin, secreted by fat cells, has regulatory functions on energy metabolism. Its low levels are predictive of future development of diabetes. Because no studies on the regulatory role of adiponectin in glucose homeostasis in Asian Indians exist, this analysis was performed to determine the prospective association of adiponectin and diabetes in subjects with impaired glucose tolerance (IGT).

RESEARCH DESIGN AND METHODS—Baseline values of plasma adiponectin, results of anthropometry, fasting and 2-h plasma glucose levels, HbA_1c, results of lipid profile, and insulin resistance were analyzed in 91 subjects with IGT (53 men and 38 women) in a primary prevention study. Reassessment of glucose tolerance was performed during 1-year review. The predictive nature of adiponectin for development of diabetes was assessed using univariate and multiple logistic regression analyses. A control group comprising healthy, normoglycemic individuals was used for comparison.

RESULTS—At follow-up, diabetes had developed in 25 of the 91 study subjects. The mean baseline adiponectin level was lower in the diabetic subjects than in the nondiabetic subjects (11.3 ± 5.5 vs. 16.7 ± 7.6 µg/ml, P = 0.0017). Low adiponectin level was a strong predictor of future development of diabetes, and HbA_1c also showed a positive predictive association. Women had higher adiponectin levels (16.4 ± 6.1 µg/ml) than men (13.9 ± 7.6 µg/ml) (P = 0.035).

CONCLUSIONS—In Asian Indians, low plasma adiponectin level was predictive of future development of diabetes.

Abbreviations: IGT, impaired glucose tolerance • NGT, normal glucose tolerance • OGTT, oral glucose tolerance test

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				C. Heidemann, Q. Sun, R. M. van Dam, J. B. Meigs, C. Zhang, S. S. Tworoger, C. S. Mantzoros, and F. B. Hu Total and High-Molecular-Weight Adiponectin and Resistin in Relation to the Risk for Type 2 Diabetes in Women Ann Intern Med, September 2, 2008; 149(5): 307 - 316. [Abstract] [Full Text] [PDF]

				K. J. Mather, T. Funahashi, Y. Matsuzawa, S. Edelstein, G. A. Bray, S. E. Kahn, J. Crandall, S. Marcovina, B. Goldstein, R. Goldberg, et al. Adiponectin, Change in Adiponectin, and Progression to Diabetes in the Diabetes Prevention Program Diabetes, April 1, 2008; 57(4): 980 - 986. [Abstract] [Full Text] [PDF]

				C. Menzaghi, V. Trischitta, and A. Doria Genetic Influences of Adiponectin on Insulin Resistance, Type 2 Diabetes, and Cardiovascular Disease Diabetes, May 1, 2007; 56(5): 1198 - 1209. [Abstract] [Full Text] [PDF]

				T. A. Hopkins, N. Ouchi, R. Shibata, and K. Walsh Adiponectin actions in the cardiovascular system Cardiovasc Res, April 1, 2007; 74(1): 11 - 18. [Abstract] [Full Text] [PDF]

				M. B. Snijder, R. J. Heine, J. C. Seidell, L. M. Bouter, C. D.A. Stehouwer, G. Nijpels, T. Funahashi, Y. Matsuzawa, I. Shimomura, and J. M. Dekker Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women: the hoorn study. Diabetes Care, November 1, 2006; 29(11): 2498 - 2503. [Abstract] [Full Text] [PDF]

				J. C. Winer, T. L. Zern, S. E. Taksali, J. Dziura, A. M. G. Cali, M. Wollschlager, A. A. Seyal, R. Weiss, T. S. Burgert, and S. Caprio Adiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4415 - 4423. [Abstract] [Full Text] [PDF]

				R. Nakashima, N. Kamei, K. Yamane, S. Nakanishi, A. Nakashima, and N. Kohno Decreased Total and High Molecular Weight Adiponectin Are Independent Risk Factors for the Development of Type 2 Diabetes in Japanese-Americans J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 3873 - 3877. [Abstract] [Full Text] [PDF]

				R. Retnakaran, A. J.G. Hanley, and B. Zinman Does Hypoadiponectinemia Explain the Increased Risk of Diabetes and Cardiovascular Disease in South Asians? Diabetes Care, August 1, 2006; 29(8): 1950 - 1954. [Full Text] [PDF]

				M. Gupta, N. Singh, and S. Verma South Asians and Cardiovascular Risk: What Clinicians Should Know Circulation, June 27, 2006; 113(25): e924 - e929. [Full Text] [PDF]

				A. M. Kanaya, C. Wassel Fyr, E. Vittinghoff, T. B. Harris, S. W. Park, B. H. Goodpaster, F. Tylavsky, and S. R. Cummings Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1. Arch Intern Med, February 13, 2006; 166(3): 350 - 356. [Abstract] [Full Text] [PDF]

				J. G. Woo, L. M. Dolan, R. Deka, R. D. Kaushal, Y. Shen, P. Pal, S. R. Daniels, and L. J. Martin Interactions Between Noncontiguous Haplotypes in the Adiponectin Gene ACDC Are Associated With Plasma Adiponectin Diabetes, February 1, 2006; 55(2): 523 - 529. [Abstract] [Full Text] [PDF]

				H. Knobler, M. Benderly, V. Boyko, S. Behar, Z. Matas, A. Rubinstein, I. Raz, and J. Wainstein Adiponectin and the development of diabetes in patients with coronary artery disease and impaired fasting glucose Eur. J. Endocrinol., January 1, 2006; 154(1): 87 - 92. [Abstract] [Full Text] [PDF]

				R. Retnakaran, B. Zinman, P. W. Connelly, M. Sermer, and A. J.G. Hanley Impaired Glucose Tolerance of Pregnancy Is a Heterogeneous Metabolic Disorder as Defined by the Glycemic Response to the Oral Glucose Tolerance Test Diabetes Care, January 1, 2006; 29(1): 57 - 62. [Abstract] [Full Text] [PDF]

				P. Balagopal, D. George, H. Yarandi, V. Funanage, and E. Bayne Reversal of Obesity-Related Hypoadiponectinemia by Lifestyle Intervention: A Controlled, Randomized Study in Obese Adolescents J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 6192 - 6197. [Abstract] [Full Text] [PDF]

				Z. T. Bloomgarden Inflammation, Atherosclerosis, and Aspects of Insulin Action Diabetes Care, September 1, 2005; 28(9): 2312 - 2319. [Full Text] [PDF]

				S. Otake, H. Takeda, Y. Suzuki, T. Fukui, S. Watanabe, K. Ishihama, T. Saito, H. Togashi, T. Nakamura, Y. Matsuzawa, et al. Association of Visceral Fat Accumulation and Plasma Adiponectin with Colorectal Adenoma: Evidence for Participation of Insulin Resistance Clin. Cancer Res., May 15, 2005; 11(10): 3642 - 3646. [Abstract] [Full Text] [PDF]

				P. A. Tataranni and E. Ortega A Burning Question: Does an Adipokine-Induced Activation of the Immune System Mediate the Effect of Overnutrition on Type 2 Diabetes? Diabetes, April 1, 2005; 54(4): 917 - 927. [Abstract] [Full Text] [PDF]

				M. B. Schulze, I. Shai, E. B. Rimm, T. Li, N. Rifai, and F. B. Hu Adiponectin and Future Coronary Heart Disease Events Among Men With Type 2 Diabetes Diabetes, February 1, 2005; 54(2): 534 - 539. [Abstract] [Full Text] [PDF]

				D. E. Laaksonen, J. Lindstrom, T. A. Lakka, J. G. Eriksson, L. Niskanen, K. Wikstrom, S. Aunola, S. Keinanen-Kiukaanniemi, M. Laakso, T. T. Valle, et al. Physical Activity in the Prevention of Type 2 Diabetes: The Finnish Diabetes Prevention Study Diabetes, January 1, 2005; 54(1): 158 - 165. [Abstract] [Full Text] [PDF]

				N. Sattar, O. Scherbakova, I. Ford, D. St. J. O'Reilly, A. Stanley, E. Forrest, P. W. MacFarlane, C. J. Packard, S. M. Cobbe, and J. Shepherd Elevated Alanine Aminotransferase Predicts New-Onset Type 2 Diabetes Independently of Classical Risk Factors, Metabolic Syndrome, and C-Reactive Protein in the West of Scotland Coronary Prevention Study Diabetes, November 1, 2004; 53(11): 2855 - 2860. [Abstract] [Full Text] [PDF]

				B. B. Duncan, M. I. Schmidt, J. S. Pankow, H. Bang, D. Couper, C. M. Ballantyne, R. C. Hoogeveen, and G. Heiss Adiponectin and the Development of Type 2 Diabetes: The Atherosclerosis Risk in Communities Study Diabetes, September 1, 2004; 53(9): 2473 - 2478. [Abstract] [Full Text] [PDF]

				A. Raji, M. D. Gerhard-Herman, M. Warren, S. G. Silverman, V. Raptopoulos, C. S. Mantzoros, and D. C. Simonson Insulin Resistance and Vascular Dysfunction in Nondiabetic Asian Indians J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 3965 - 3972. [Abstract] [Full Text] [PDF]

				D. Prabhakaran and S. S Anand The metabolic syndrome: an emerging risk state for cardiovascular disease Vascular Medicine, February 1, 2004; 9(1): 55 - 68. [Abstract] [PDF]