HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Masding, M. G. Articles by Sandeman, D. D. Search for Related Content PubMed PubMed Citation Articles by Masding, M. G. Articles by Sandeman, D. D. Social Bookmarking                What's this?

Premenopausal Advantages in Postprandial Lipid Metabolism Are Lost in Women With Type 2 Diabetes

¹ Southampton University Hospitals NHS Trust, Southampton, U.K
² Institute of Human Nutrition, University of Southampton, Southampton, U.K

Address correspondence and reprint requests to Dr. Mike Masding, Specialist Registrar in Diabetes & Endocrinology, Poole Hospital NHS Trust, Longfleet Road, Poole BH15 2JB, U.K. E-mail: mike.mas{at}lineone.net

OBJECTIVE—Women with type 2 diabetes appear to lose the protection against cardiovascular disease afforded by estrogens. We examined the effects of menopausal status on postprandial clearance of dietary fat in healthy and diabetic women.

RESEARCH DESIGN AND METHODS—Fasting subjects (premenopausal and postmenopausal control subjects, premenopausal and postmenopausal diabetic women, all n = 8) were given a meal containing the stable isotope 1,1,1-¹³C-tripalmitin, with blood and breath sampled for 6 and 24 h, respectively, in the postprandial period. Lower levels of ¹³C-palmitic acid (¹³C-PA) in the triglyceride fraction implies more efficient chylomicron clearance, lower levels of ¹³C-PA in the nonesterified fatty acid (NEFA) fraction implies improved dietary NEFA entrapment, and higher levels of ¹³CO₂ in the breath denote more efficient of oxidation of dietary-derived lipid.

RESULTS—In diabetic women, there were no differences between the pre- and postmenopausal groups for any of these parameters. In contrast, premenopausal control subjects, compared with postmenopausal control subjects, had lower ¹³C-PA in the triglyceride fraction area under the curve (AUC) (premenopausal median [range] 25.2 [12.1–49.4 mmol/l] per 6 h, postmenopausal 48.5 [15.5–77.2 mmol/l] per 6 h; P < 0.01) and higher ¹³CO₂ levels in the breath AUC (premenopausal 22.5 [18.0–31.5%] of administered dose, postmenopausal 17.2 [11.2–31.5%] of administered dose; P < 0.01) with no difference between groups in levels of ¹³C-PA in the NEFA fraction AUC.

CONCLUSIONS—The premenopausal advantage in clearance of dietary lipid is not seen in premenopausal diabetic women. This is likely to promote an atherogenic lipoprotein profile and may contribute to the loss of cardiovascular disease protection seen in diabetic women.

Abbreviations: AUC, area under the curve • CHD, coronary heart disease • IRMS, isotope ratio mass spectrometry • LPL, lipoprotein lipase • NEFA, nonesterified fatty acid • TRL, triglyceride-rich lipoprotein • ¹³C-PA, ¹³C-palmitic acid

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				D. B. Carr, K. M. Utzschneider, R. L. Hull, J. Tong, T. M. Wallace, K. Kodama, J. B. Shofer, S. R. Heckbert, E. J. Boyko, W. Y. Fujimoto, et al. Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes. Diabetes Care, September 1, 2006; 29(9): 2078 - 2083. [Abstract] [Full Text] [PDF]