HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Thanopoulou, A. C. Articles by Tenconi, M.-T. P. Search for Related Content PubMed PubMed Citation Articles by Thanopoulou, A. C. Articles by Tenconi, M.-T. P. Social Bookmarking                What's this?

Dietary Fat Intake as Risk Factor for the Development of Diabetes

Multinational, multicenter study of the Mediterranean Group for the Study of Diabetes (MGSD)

¹ Diabetes Center, 2nd Medical Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
² Department of Clinics and Applied Medical Therapy, University "La Sapienza," Rome, Italy
³ Department of Internal Medicine, Alexandria Faculty of Medicine, Alexandria, Egypt
⁴ Diabetes Center, Institute for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Yugoslavia
⁵ Diabetes Center, 1st Department of Propedeutic Medicine, Athens University School of Medicine, Laiko General Hospital, Athens, Greece
⁶ Diabetes Center, "NIMTS" Hospital, Athens, Greece
⁷ Service de Medicine Interne "A" C.H.U., Oran, Algeria
⁸ Diabetes Center "St. Luca," Sofia, Bulgaria
⁹ Dipartimento di Medicina Preventiva, Occupazionale e di Communita, Sezione di Igiene, Università degli studi di Pavia, Italy

OBJECTIVE—To investigate the role of dietary factors in the development of type 2 diabetes.

RESEARCH DESIGN AND METHODS—In the context of the Multinational MGSD Nutrition Study, three groups of subjects were studied: 204 subjects with recently diagnosed diabetes (RDM), 42 subjects with undiagnosed diabetes (UDM) (American Diabetes Association criteria—fasting plasma glucose [FPG] 126 mg/dl), and 55 subjects with impaired fasting glucose (IFG) (FPG 110 and <126 mg/dl). Each group was compared with a control group of nondiabetic subjects, matched one by one for center, sex, age, and BMI. Nutritional habits were evaluated by a dietary history method, validated against the 3-day diet diary. In RDM, the questionnaire referred to the nutritional habits before the diagnosis of diabetes. Demographic data were collected, and anthropometrical and biochemical measurements were taken.

RESULTS—Compared with control subjects, RDM more frequently had a family history of diabetes (49.0 vs. 14.2%; P < 0.001), exercised less (exercise index 53.5 vs. 64.4; P < 0.01), and more frequently had sedentary professions (47.5 vs. 27.4%; P < 0.001). Carbohydrates contributed less to their energy intake (53.5 vs. 55.1%; P < 0.05), whereas total fat (30.2 ± 0.5 vs. 27.8 ± 0.5%; P < 0.001) and animal fat (12.2 ± 0.3 vs. 10.8 ± 0.3%; P < 0.01) contributed more and the plant-to-animal fat ratio was lower (1.5 ± 0.1 vs. 1.8 ± 0.1; P < 0.01). UDM more frequently had a family history of diabetes (38.1 vs. 19.0%; P < 0.05) and sedentary professions (58.5 vs. 34.1%; P < 0.05), carbohydrates contributed less to their energy intake (47.6 ± 1.7 vs. 52.8 ± 1.4%; P < 0.05), total fat (34.7 ± 1.5 vs. 30.4 ± 1.2%; P < 0.05) and animal fat (14.2 ± 0.9 vs. 10.6 ± 0.7%; P < 0.05) contributed more, and the plant-to-animal fat ratio was lower (1.6 ± 0.2 vs. 2.3 ± 0.4; P < 0.05). IFG differed only in the prevalence of family history of diabetes (32.7 vs. 16.4%; P < 0.05).

CONCLUSIONS—Our data support the view that increased animal fat intake is associated with the presence of diabetes.

Abbreviations: 3-DDD, 3-Day Diet Diary • FPG, fasting plasma glucose • IGT, impaired glucose tolerance • IFG, impaired fasting glucose • RDM, recently diagnosed diabetes • UDM, unknown diabetes

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. H. Auchincloss, A. V. Diez Roux, D. G. Brown, E. S. O'Meara, and T. E. Raghunathan Association of Insulin Resistance with Distance to Wealthy Areas: The Multi-Ethnic Study of Atherosclerosis Am. J. Epidemiol., February 15, 2007; 165(4): 389 - 397. [Abstract] [Full Text] [PDF]

				W. El-Assaad, J. Buteau, M.-L. Peyot, C. Nolan, R. Roduit, S. Hardy, E. Joly, G. Dbaibo, L. Rosenberg, and M. Prentki Saturated Fatty Acids Synergize with Elevated Glucose to Cause Pancreatic {beta}-Cell Death Endocrinology, September 1, 2003; 144(9): 4154 - 4163. [Abstract] [Full Text] [PDF]

				From the Library Br. J. Ophthalmol., August 1, 2003; 87(8): 1056 - 1056. [Full Text] [PDF]