Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hayashi, T.
Right arrow Articles by Fujimoto, W. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hayashi, T.
Right arrow Articles by Fujimoto, W. Y.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Diabetes Care 26:650-655, 2003
© 2003 by the American Diabetes Association, Inc.

Epidemiology/Health Services/Psychosocial Research
Original Article

Visceral Adiposity and the Risk of Impaired Glucose Tolerance

A prospective study among Japanese Americans

Tomoshige Hayashi, MD, PHD1,2, Edward J. Boyko, MD, MPH1,2, Donna L. Leonetti, PHD3, Marguerite J. McNeely, MD, MPH2, Laura Newell-Morris, PHD3, Steven E. Kahn, MB, CHB2 and Wilfred Y. Fujimoto, MD2

1 Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington
2 Department of Medicine, University of Washington, Seattle, Washington
3 Department of Anthropology, University of Washington, Seattle, Washington

OBJECTIVE—Greater visceral adiposity, higher insulin resistance, and impaired insulin secretion increase the risk of type 2 diabetes. Whether visceral adiposity increases risk of impaired glucose tolerance (IGT) independent of other adipose depots, insulin resistance, and insulin secretion is not known.

RESEARCH DESIGN AND METHODS—Study subjects included 128 Japanese Americans with normal glucose tolerance at entry. Baseline variables included plasma glucose and insulin measured after an overnight fast and during a 75-g oral glucose tolerance test, fat areas by computed tomography, insulin secretion (incremental insulin response [IIR] [30 min insulin - fasting insulin]/30 min glucose), and insulin resistance index (homeostasis model assessment for insulin resistance [HOMA-IR]).

RESULTS—During the 10- to 11-year follow-up period, we confirmed 57 cases of IGT. Significant predictors of IGT included intra-abdominal fat area (IAFA) (odds ratio [OR] for a 1 SD increase 3.82, 95% CI 1.63–8.94 at a fasting plasma glucose [FPG] level of 4.5 mmol/l), HOMA-IR (2.41, 1.15–5.04), IIR (0.30, 0.13–0.69 at an FPG level of 4.5 mmol/l), the interactions of IAFA by FPG (P = 0.003), and IIR by FPG (P = 0.030) after adjusting for age, sex, FPG, and BMI. The multiple-adjusted OR of IAFA increased and that of IIR decreased as FPG level decreased because of these interactions. Even after adjustment for total fat area, total subcutaneous fat area, or abdominal subcutaneous fat area, all of these associations remained a significant predictor of IGT incidence.

CONCLUSIONS—Greater visceral adiposity increases the risk of IGT independent of insulin resistance, insulin secretion, and other adipose depots in Japanese Americans.

Abbreviations: CT, computed tomography • FPG, fasting plasma glucose • HOMA-IR, homeostasis model assessment for insulin resistance • IAFA, intra-abdominal fat area • IGT, impaired glucose tolerance • IIR, incremental insulin response • OGTT, oral glucose tolerance test • OR, odds ratio • NGT, normal glucose tolerance • TFA, total fat area


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 DiabetesHome page
A. J.G. Hanley and L. E. Wagenknecht
Abdominal Adiposity and Diabetes Risk: The Importance of Precise Measures and Longitudinal Studies
Diabetes, May 1, 2008; 57(5): 1153 - 1155.
[Full Text] [PDF]

Home page
 CirculationHome page
C. S. Fox, J. M. Massaro, U. Hoffmann, K. M. Pou, P. Maurovich-Horvat, C.-Y. Liu, R. S. Vasan, J. M. Murabito, J. B. Meigs, L. A. Cupples, et al.
Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study
Circulation, July 3, 2007; 116(1): 39 - 48.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
Y. Song, J. E. Manson, L. Tinker, B. V. Howard, L. H. Kuller, L. Nathan, N. Rifai, and S. Liu
Insulin Sensitivity and Insulin Secretion Determined by Homeostasis Model Assessment and Risk of Diabetes in a Multiethnic Cohort of Women: The Women's Health Initiative Observational Study
Diabetes Care, July 1, 2007; 30(7): 1747 - 1752.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
E. Nisoli, E. Clementi, M. O. Carruba, and S. Moncada
Defective Mitochondrial Biogenesis: A Hallmark of the High Cardiovascular Risk in the Metabolic Syndrome?
Circ. Res., March 30, 2007; 100(6): 795 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
A Majuri, M Santaniemi, K Rautio, A Kunnari, J Vartiainen, A Ruokonen, Y A Kesaniemi, J S Tapanainen, O Ukkola, and L Morin-Papunen
Rosiglitazone treatment increases plasma levels of adiponectin and decreases levels of resistin in overweight women with PCOS: a randomized placebo-controlled study
Eur. J. Endocrinol., February 1, 2007; 156(2): 263 - 269.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
T. Hayashi, E. J. Boyko, M. J. McNeely, D. L. Leonetti, S. E. Kahn, and W. Y. Fujimoto
Minimum Waist and Visceral Fat Values for Identifying Japanese Americans at Risk for the Metabolic Syndrome
Diabetes Care, January 1, 2007; 30(1): 120 - 127.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. M. Utzschneider and S. E. Kahn
The Role of Insulin Resistance in Nonalcoholic Fatty Liver Disease
J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 4753 - 4761.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. L. Vega, B. Adams-Huet, R. Peshock, D. Willett, B. Shah, and S. M. Grundy
Influence of Body Fat Content and Distribution on Variation in Metabolic Risk
J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4459 - 4466.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. Bajaj and O. Ben-Yehuda
A Big Fat Wedding: Association of Adiponectin With Coronary Vascular Lesions
J. Am. Coll. Cardiol., September 19, 2006; 48(6): 1163 - 1165.
[Full Text] [PDF]

Home page
 J. Lipid Res.Home page
A. M. Bodles, V. Varma, A. Yao-Borengasser, B. Phanavanh, C. A. Peterson, R. E. McGehee Jr., N. Rasouli, M. Wabitsch, and P. A. Kern
Pioglitazone induces apoptosis of macrophages in human adipose tissue
J. Lipid Res., September 1, 2006; 47(9): 2080 - 2088.
[Abstract] [Full Text] [PDF]

Home page
 Home Health Care Management PracticeHome page
C. Ozawa, P. T. Alpert, and S. K. Miller
Culturally Sensitive Treatment of Metabolic Syndrome in Asian Americans
Home Health Care Management Practice, August 1, 2006; 18(5): 394 - 402.
[Abstract] [PDF]

Home page
 Diabetes CareHome page
K. H. Liu, Y. L. Chan, W. B. Chan, J. C. N. Chan, and C. W. W. Chu
Mesenteric Fat Thickness Is an Independent Determinant of Metabolic Syndrome and Identifies Subjects With Increased Carotid Intima-Media Thickness
Diabetes Care, February 1, 2006; 29(2): 379 - 384.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. M. Grundy, J. I. Cleeman, S. R. Daniels, K. A. Donato, R. H. Eckel, B. A. Franklin, D. J. Gordon, R. M. Krauss, P. J. Savage, S. C. Smith Jr, et al.
Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Circulation, October 25, 2005; 112(17): 2735 - 2752.
[Full Text] [PDF]

Home page
 DiabetesHome page
J. Tong, W. Y. Fujimoto, S. E. Kahn, D. S. Weigle, M. J. McNeely, D. L. Leonetti, J. B. Shofer, and E. J. Boyko
Insulin, C-Peptide, and Leptin Concentrations Predict Increased Visceral Adiposity at 5- and 10-Year Follow-Ups in Nondiabetic Japanese Americans
Diabetes, April 1, 2005; 54(4): 985 - 990.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
D. B. Carr, K. M. Utzschneider, E. J. Boyko, P. J. Asberry, R. L. Hull, K. Kodama, H. S. Callahan, C. C. Matthys, D. L. Leonetti, R. S. Schwartz, et al.
A Reduced-Fat Diet and Aerobic Exercise in Japanese Americans With Impaired Glucose Tolerance Decreases Intra-Abdominal Fat and Improves Insulin Sensitivity but not {beta}-Cell Function
Diabetes, February 1, 2005; 54(2): 340 - 347.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
M. Anjana, S. Sandeep, R. Deepa, K. S. Vimaleswaran, S. Farooq, and V. Mohan
Visceral and Central Abdominal Fat and Anthropometry in Relation to Diabetes in Asian Indians
Diabetes Care, December 1, 2004; 27(12): 2948 - 2953.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. M. Utzschneider, D. B. Carr, R. L. Hull, K. Kodama, J. B. Shofer, B. M. Retzlaff, R. H. Knopp, and S. E. Kahn
Impact of Intra-Abdominal Fat and Age on Insulin Sensitivity and {beta}-Cell Function
Diabetes, November 1, 2004; 53(11): 2867 - 2872.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
D. B. Carr, K. M. Utzschneider, R. L. Hull, K. Kodama, B. M. Retzlaff, J. D. Brunzell, J. B. Shofer, B. E. Fish, R. H. Knopp, and S. E. Kahn
Intra-Abdominal Fat Is a Major Determinant of the National Cholesterol Education Program Adult Treatment Panel III Criteria for the Metabolic Syndrome
Diabetes, August 1, 2004; 53(8): 2087 - 2094.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2003 by the American Diabetes Association.