|
 |
|
|||||||
|
|||||||||
© 2003 by the American Diabetes Association, Inc.
Reviews/Commentaries/Position Statements |
Systematic Review of Herbs and Dietary Supplements for Glycemic Control in Diabetes
1 Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, Boston, Massachusetts
2 Division of General Medicine and Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
ABSTRACT
OBJECTIVE—To conduct a systematic review of the published literature on the efficacy and safety of herbal therapies and vitamin/mineral supplements for glucose control in patients with diabetes.
RESEARCH DESIGN AND METHODS—We conducted an electronic literature search of MEDLINE, OLDMEDLINE, Cochrane Library Database, and HealthSTAR, from database inception to May 2002, in addition to performing hand searches and consulting with experts in the field. Available clinical studies published in the English language that used human participants and examined glycemic control were included. Data were extracted in a standardized manner, and two independent investigators assessed methodological quality of randomized controlled trials using the Jadad scale.
RESULTS—A total of 108 trials examining 36 herbs (single or in combination) and 9 vitamin/mineral supplements, involving 4,565 patients with diabetes or impaired glucose tolerance, met the inclusion criteria and were analyzed. There were 58 controlled clinical trials involving individuals with diabetes or impaired glucose tolerance (42 randomized and 16 nonrandomized trials). Most studies involved patients with type 2 diabetes. Heterogeneity and the small number of studies per supplement precluded formal meta-analyses. Of these 58 trials, the direction of the evidence for improved glucose control was positive in 76% (44 of 58). Very few adverse effects were reported.
CONCLUSIONS—There is still insufficient evidence to draw definitive conclusions about the efficacy of individual herbs and supplements for diabetes; however, they appear to be generally safe. The available data suggest that several supplements may warrant further study. The best evidence for efficacy from adequately designed randomized controlled trials (RCTs) is available for Coccinia indica and American ginseng. Chromium has been the most widely studied supplement. Other supplements with positive preliminary results include Gymnema sylvestre, Aloe vera, vanadium, Momordica charantia, and nopal.
Abbreviations: CAM, complementary and alternative medicine • GTT, glucose tolerance test • RCT, randomized controlled trial • TCM, Traditional Chinese medicine
CiteULike 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  R. Kuriyan, R. Rajendran, G. Bantwal, and A. V. Kurpad Effect of Supplementation of Coccinia cordifolia Extract on Newly Detected Diabetic Patients Diabetes Care, February 1, 2008; 31(2): 216 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Zhang, X. Li, W. Lv, Y. Yang, H. Gao, J. Yang, Y. Shen, and G. Ning Ginsenoside Re Reduces Insulin Resistance through Inhibition of c-Jun NH2-Terminal Kinase and Nuclear Factor-{kappa}B Mol. Endocrinol., January 1, 2008; 22(1): 186 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
American Diabetes Association Nutrition Recommendations and Interventions for Diabetes: A position statement of the American Diabetes Association Diabetes Care, January 1, 2008; 31(Supplement_1): S61 - S78. [Full Text] [PDF]
|
|
|
|
|
|
N. Kleefstra, S. T. Houweling, S. J.L. Bakker, S. Verhoeven, R. O.B. Gans, B. Meyboom-de Jong, and H. J.G. Bilo Chromium Treatment Has No Effect in Patients With Type 2 Diabetes in a Western Population: A randomized, double-blind, placebo-controlled trial Diabetes Care, May 1, 2007; 30(5): 1092 - 1096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
American Diabetes Association Nutrition Recommendations and Interventions for Diabetes: A position statement of the American Diabetes Association Diabetes Care, January 1, 2007; 30(suppl_1): S48 - S65. [Full Text] [PDF]
|
|
|
|
|
|
American Diabetes Association Nutrition Recommendations and Interventions for Diabetes-2006: A position statement of the American Diabetes Association. Diabetes Care, September 1, 2006; 29(9): 2140 - 2157. [Full Text] [PDF]
|
|
|
|
|
|
M. Collins and J. R. McFarlane An Exploratory Study Into the Effectiveness of a Combination of Traditional Chinese Herbs in the Management of Type 2 Diabetes Diabetes Care, April 1, 2006; 29(4): 945 - 946. [Full Text] [PDF]
|
|
|
|
|
|
N. Kleefstra, S. T. Houweling, F. G.A. Jansman, K. H. Groenier, R. O.B. Gans, B. Meyboom-de Jong, S. J.L. Bakker, and H. J.G. Bilo Chromium Treatment Has No Effect in Patients With Poorly Controlled, Insulin-Treated Type 2 Diabetes in an Obese Western Population: A randomized, double-blind, placebo-controlled trial. Diabetes Care, March 1, 2006; 29(3): 521 - 525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Garrow and L. E. Egede Association Between Complementary and Alternative Medicine Use, Preventive Care Practices, and Use of Conventional Medical Services Among Adults With Diabetes Diabetes Care, January 1, 2006; 29(1): 15 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Gunton, N. W. Cheung, R. Hitchman, G. Hams, C. Sullivan, K. Foster-Powell, and A. McElduff Chromium Supplementation Does Not Improve Glucose Tolerance, Insulin Sensitivity, or Lipid Profile: A Randomized, Placebo-Controlled, Double-Blind Trial of Supplementation in Subjects With Impaired Glucose Tolerance: Response to Komorowski and Juturu Diabetes Care, July 1, 2005; 28(7): 1842 - 1843. [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Sievenpiper, J. T. Arnason, L. A. Leiter, and V. Vuksan Decreasing, Null and Increasing Effects of Eight Popular Types of Ginseng on Acute Postprandial Glycemic Indices in Healthy Humans: The Role of Ginsenosides J. Am. Coll. Nutr., June 1, 2004; 23(3): 248 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ludvik, B. Neuffer, and G. Pacini Efficacy of Ipomoea batatas (Caiapo) on Diabetes Control in Type 2 Diabetic Subjects Treated With Diet Diabetes Care, February 1, 2004; 27(2): 436 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Unproven Therapies Diabetes Care, January 1, 2004; 27(90001): s135 - 135. [Full Text] [PDF]
|
|
|
|
 |
|
 OTHER ARTICLES NOTED (25 Apr 2003 to 18 Jul 2003) Evid. Based Nurs., October 1, 2003; 6(4): e1 - 12. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Diabetes | Diabetes Care | Clinical Diabetes | Diabetes Spectrum |