Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pankow, J. S.
Right arrow Articles by Golden, S. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pankow, J. S.
Right arrow Articles by Golden, S. H.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Diabetes Care 27:77-82, 2004
© 2004 by the American Diabetes Association, Inc.

Epidemiology/Health Services/Psychosocial Research
Original Article

Fasting Plasma Free Fatty Acids and Risk of Type 2 Diabetes

The Atherosclerosis Risk in Communities study

James S. Pankow, PHD1, Bruce B. Duncan, MD, PHD2, Maria Inês Schmidt, MD, PHD2, Christie M. Ballantyne, MD3, David J. Couper, PHD4, Ron C. Hoogeveen, PHD3 and Sherita H. Golden, MD5

1 Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota
2 Department of Social Medicine, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil, and the Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina
3 Department of Medicine, Baylor College of Medicine, Houston, Texas
4 Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, North Carolina
5 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland

Address correspondence and reprint requests to James S. Pankow, Division of Epidemiology, University of Minnesota, 1300 South Second St., Suite 300, Minneapolis, MN 55454. E-mail: pankow{at}epi.umn.edu

OBJECTIVE—To evaluate whether plasma levels of free fatty acids (FFAs) are independently associated with incidence of type 2 diabetes.

RESEARCH DESIGN AND METHODS—A case-cohort design was used to randomly select 580 incident cases of diabetes and 566 noncases from 10,275 African-American and white men and women in the Atherosclerosis Risk in Communities study, aged 45–64 years and without prevalent diabetes at the baseline exam. Incident diabetes was ascertained at three exams over 9 years of follow-up. FFA levels were measured in plasma samples collected at the baseline exam.

RESULTS—At baseline, FFA level was inversely associated with height and positively associated with female sex, BMI, waist circumference, waist-to-hip ratio, heart rate, plasma triglycerides, and an inflammation score quantifying levels of six systemic inflammation markers. Relative risks for incident diabetes (fourth vs. first quartile of FFAs) were increased in a basic model adjusted for age, sex, race, and center (hazard ratio 1.68, 95% CI 1.20–2.34) and in a model further adjusted for baseline fasting glucose, insulin, BMI, waist circumference, triglycerides, and the inflammation score (1.63, 1.04–2.57). Relative risks associated with a greater FFA level were lowest among those of normal weight and highest among the obese, but a formal test of interaction between FFAs and BMI was not statistically significant.

CONCLUSIONS—Individuals with higher fasting levels of plasma FFAs were at modestly higher risk of type 2 diabetes in this cohort of middle-aged adults.

Abbreviations: ARIC, Atherosclerosis Risk in Communities • FFA, free fatty acid • HOMA-IR, homeostasis model assessment of insulin resistance


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
M. L. Jehn, E. Guallar, J. M. Clark, D. Couper, B. B. Duncan, C. M. Ballantyne, R. C. Hoogeveen, Z. L. Harris, and J. S. Pankow
A Prospective Study of Plasma Ferritin Level and Incident Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study
Am. J. Epidemiol., May 1, 2007; 165(9): 1047 - 1054.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
M. R. Carnethon, R. J. Prineas, M. Temprosa, Z.-M. Zhang, G. Uwaifo, M. E. Molitch, and for the Diabetes Prevention Program Research Group
The Association Among Autonomic Nervous System Function, Incident Diabetes, and Intervention Arm in the Diabetes Prevention Program
Diabetes Care, April 1, 2006; 29(4): 914 - 919.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
K. Esposito and D. Giugliano
Diet and inflammation: a link to metabolic and cardiovascular diseases
Eur. Heart J., January 1, 2006; 27(1): 15 - 20.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
J. V. Patel, A. Vyas, D. Prabhakaran, D. Bhatnagar, P. N. Durrington, A. Heald, E. A. Hughes, M. I. Mackness, K. S. Reddy, and J. K. Cruickshank
Nonesterified Fatty Acids as Mediators of Glucose Intolerance in Indian Asian Populations
Diabetes Care, June 1, 2005; 28(6): 1505 - 1507.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. M. Poynten, S. K. Gan, A. D. Kriketos, L. V. Campbell, and D. J. Chisholm
Circulating Fatty Acids, Non-High Density Lipoprotein Cholesterol, and Insulin-Infused Fat Oxidation Acutely Influence Whole Body Insulin Sensitivity in Nondiabetic Men
J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 1035 - 1040.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2004 by the American Diabetes Association.