HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hadjadj, S. Search for Related Content PubMed PubMed Citation Articles by Hadjadj, S. Social Bookmarking                What's this?

Different Patterns of Insulin Resistance in Relatives of Type 1 Diabetic Patients With Retinopathy or Nephropathy

The Genesis France-Belgium Study

¹ Department of Endocrinology and Diabetology, University Hospital, Poitiers, France
² Laboratoire de Nutrition Humaine, Faculté de Médecine X Bichat, Paris, France
³ Department of Biochimie, Faculté de Médecine d’Angers, Angers, France
⁴ Department of Endocrinology and Diabetology, Saint-Louis Hospital, Assistance Publique Hôpitaux de Paris, Paris, France
⁵ Diabetes Division, Nutrition and Metabolic Disorders, Department of Medicine, Centre Hospitalier Universitaire Sart Tilman, Liege, Belgium
⁶ Department of Nutrition and Diabetology, Centre Hospitalier Universitaire Groupe Sud, Pessac, France
⁷ Department of Diabetology, Begin Military Hospital, Saint Mandé, France
⁸ Department of Endocrinology, Diabetology and Nutrition, Bichat Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France
⁹ Department of Nephrology, Sainte Marguerite Hospital, Marseille, France
¹⁰ Department of Endocrinology, University Hospital, Nimes, France

Address correspondence and reprint requests to Michel Marre, Department of Endocrinology, DiabetologyNutrition, Bichat Hospital, Assistance Publique des Hôpitaux de Paris, 46 rue Henri Huchard, 75877 Paris Cedex 18, France. E-mail: michel.marre{at}bch.ap-hop-paris.fr

OBJECTIVE—Insulin resistance may be a risk factor for diabetic microangiopathy, which may have a familial component. We carried out a family-based study to determine which components of the insulin resistance syndrome are associated with diabetic retinopathy and nephropathy in type 1 diabetes.

RESEARCH DESIGN AND METHODS—The Genesis France-Belgium Study is a multicenter binational study designed to investigate the genetic factors involved in the microvascular complications of type 1 diabetes using a family-based design. Probands were type 1 diabetic patients with diabetic retinopathy (classified as background, preproliferative, or proliferative) and possibly diabetic nephropathy (absent, incipient, established, or advanced). The insulin resistance score of their first-degree relatives was calculated according to their BMI and history of arterial hypertension, lipid disorders, and type 2 diabetes.

RESULTS—The insulin resistance score of relatives was positively correlated with the albumin excretion rate (P = 0.0009) and fasting plasma glucose (P = 0.0003) and HbA_1c (P < 0.0001) concentrations. This score was higher in the relatives of probands with than in those without diabetic nephropathy (P = 0.0370). Similarly, it was higher in relatives of subjects with proliferative diabetic retinopathy than in those of probands without, even after controlling for subjects with versus without diabetic nephropathy (P = 0.0379). However, the components of the insulin resistance score in relatives differed according to the severity of diabetic retinopathy or nephropathy in the probands. Obesity and history of arterial hypertension were most common in relatives of probands with proliferative diabetic retinopathy, whereas obesity and history of lipid disorders were most common in the relatives of probands with diabetic nephropathy.

CONCLUSIONS—Familial insulin resistance segregates with diabetic complications: lipid disorders and obesity segregate with diabetic nephropathy, whereas arterial hypertension and obesity segregate with diabetic retinopathy.

Abbreviations: AER, albumin excretion rate • HOMA-IR, homeostasis model assessment of insulin resistance • SBP, systolic blood pressure • UAE, urinary albumin excretion • WHO, World Health Organization

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				L. Tarnow, P.-H. Groop, S. Hadjadj, G. Kazeem, F. Cambien, M. Marre, C. Forsblom, H.-H. Parving, D. Tregouet, A. Thevard, et al. European rational approach for the genetics of diabetic complications EURAGEDIC: patient populations and strategy Nephrol. Dial. Transplant., January 1, 2008; 23(1): 161 - 168. [Abstract] [Full Text] [PDF]

				L. M. Thorn, C. Forsblom, J. Fagerudd, K. Pettersson-Fernholm, R. Kilpikari, P.-H. Groop, and on behalf of the FinnDiane Study Group Clustering of Risk Factors in Parents of Patients With Type 1 Diabetes and Nephropathy Diabetes Care, May 1, 2007; 30(5): 1162 - 1167. [Abstract] [Full Text] [PDF]

				S. Hadjadj, L. Tarnow, C. Forsblom, G. Kazeem, M. Marre, P.-H. Groop, H.-H. Parving, F. Cambien, D. A. Tregouet, I. G. Gut, et al. Association between Angiotensin-Converting Enzyme Gene Polymorphisms and Diabetic Nephropathy: Case-Control, Haplotype, and Family-Based Study in Three European Populations J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1284 - 1291. [Abstract] [Full Text] [PDF]

				N. Vionnet, D. Tregouet, G. Kazeem, I. Gut, P.-H. Groop, L. Tarnow, H.-H. Parving, S. Hadjadj, C. Forsblom, M. Farrall, et al. Analysis of 14 Candidate Genes for Diabetic Nephropathy on Chromosome 3q in European Populations: Strongest Evidence for Association With a Variant in the Promoter Region of the Adiponectin Gene Diabetes, November 1, 2006; 55(11): 3166 - 3174. [Abstract] [Full Text] [PDF]

				P. Herrero, L. R. Peterson, J. B. McGill, S. Matthew, D. Lesniak, C. Dence, and R. J. Gropler Increased Myocardial Fatty Acid Metabolism in Patients With Type 1 Diabetes Mellitus J. Am. Coll. Cardiol., February 7, 2006; 47(3): 598 - 604. [Abstract] [Full Text] [PDF]