HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pundziute-Lyckå, A. Articles by Dahlquist, G. Search for Related Content PubMed PubMed Citation Articles by Pundziute-Lyckå, A. Articles by Dahlquist, G. Social Bookmarking                What's this?

Diet, Growth, and the Risk for Type 1 Diabetes in Childhood

A matched case-referent study

Aust Pundzit-Lyckå, PHD¹, Lars-Åke Persson, PHD², Gunilla Cedermark³, Agneta Jansson-Roth⁴, Ulla Nilsson⁵, Vera Westin⁶ and Gisela Dahlquist, PHD¹

¹ Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden
² Department of Mother’s and Children’s Health, International Maternal and Child Health, Uppsala University, Uppsala, Sweden
³ Department of Pediatrics, Danderyd Hospital, Danderyd, Sweden
⁴ Sachs’ Children’s Hospital at South Stockholm General Hospital, Stockholm, Sweden
⁵ Pediatric Clinic, St. Görans Hospital, Stockholm, Sweden
⁶ Children’s Hospital at Huddinge University Hospital, Stockholm, Sweden

Address correspondence and reprint requests to Aust Pundzit-Lyckå, Department of Clinical Sciences, Pediatrics, Umeå University 901 85 Umeå, Sweden. E-mail: auste.pundziute.lycka{at}pediatri.umu.se

OBJECTIVE— To study the association between type 1 diabetes risk and previous intake of energy, accounting for body size and previous intake of nutrients and foods, accounting for the energy intake.

RESEARCH DESIGN AND METHODS—We conducted an incident population-based case-referent study in Stockholm, Sweden, including 99 of 100 eligible 7- to 14-year-old diabetic children and 180 of 200 age-, sex-, and area-matched referent children identified through the Swedish population register. Average daily energy and nutrient intake 1 year before diabetes diagnosis/interview was estimated using the food frequency questionnaire with assessment of consumed food amounts. Mean SD scores of growth measurements taken during the last 4 years before the diagnosis were used. Odds ratios (ORs) were calculated by conditional logistic regression.

RESULTS—Average intake of energy, carbohydrate, fat, and protein was significantly higher among the case subjects as well as mean weight-for-age SD score. Higher energy intake and weight-for-age were both associated with increased diabetes risk after adjustment for each other: OR (95% CI) for medium and high levels of energy intake were 1.33 (0.52–3.42) and 5.23 (1.67–16.38), respectively, and for weight-for-age were 3.20 (1.30–7.88) and 3.09 (1.16–8.22), respectively. High intake of carbohydrates, especially disaccharides and sucrose, increased diabetes risk.

CONCLUSIONS— Higher energy intake and larger body size were independently associated with increased diabetes risk. Of the different nutrients, higher intake of carbohydrates, particularly disaccharides and sucrose, increased the risk. Lifestyle habits leading to higher energy intake and more rapid growth in childhood may contribute to the increase of childhood-onset type 1 diabetes by different mechanisms.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. Gimenez, E. Aguilera, C. Castell, N. de Lara, J. Nicolau, and I. Conget Relationship Between BMI and Age at Diagnosis of Type 1 Diabetes in a Mediterranean Area in the Period of 1990-2004 Diabetes Care, June 1, 2007; 30(6): 1593 - 1595. [Full Text] [PDF]

				M. Eliasson and G. Bostrom Chapter 5.2: Major public health problems -- diabetes Scand J Public Health, May 1, 2006; 34(3): 59 - 68. [PDF]

				N. A. Sherry, E. B. Tsai, and K. C. Herold Natural History of {beta}-Cell Function in Type 1 Diabetes Diabetes, December 1, 2005; 54(suppl_2): S32 - S39. [Abstract] [Full Text] [PDF]