Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ponce-de-Leon, A.
Right arrow Articles by Sifuentes-Osornio, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ponce-de-Leon, A.
Right arrow Articles by Sifuentes-Osornio, J.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Diabetes Care 27:1584-1590, 2004
© 2004 by the American Diabetes Association, Inc.

Epidemiology/Health Services/Psychosocial Research
Original Article

Tuberculosis and Diabetes in Southern Mexico

Alfredo Ponce-de-Leon, MD1, Ma. de Lourdes Garcia-Garcia, MD, DRSC2, Ma. Cecilia Garcia-Sancho, MD, MSC3, Francisco J. Gomez-Perez, MD1, Jose Luis Valdespino-Gomez, MD, MPH2, Gustavo Olaiz-Fernandez, MD2, Rosalba Rojas, MD2, Leticia Ferreyra-Reyes, MD2, Bulmaro Cano-Arellano, BA2, Miriam Bobadilla, DRSC1, Peter M. Small, MD4 and Jose Sifuentes-Osornio, MD1

1 National Institute of Medical Sciences and Nutrition, Salvador Zubirán, Distrito Federal, Mexico
2 National Institute of Public Health, Cuernavaca, Mexico
3 National Institute of Respiratory Diseases, Distrito Federal, Mexico
4 Stanford University, Stanford, California

Address correspondence and reprint requests to Ma. de Lourdes García-García, Instituto Nacional de Salud Pública, Ave. Universidad No. 655, Cuernavaca, México, 62508. E-mail: garcigar{at}correo.insp.mx

OBJECTIVE—To determine the impact of diabetes on the rates of tuberculosis in a region where both diseases are prevalent.

RESEARCH DESIGN AND METHODS—Data from a population-based cohort of patients with pulmonary tuberculosis undergoing clinical and mycobacteriologic evaluation (isolation, identification, drug-susceptibility testing, and IS6110-based genotyping and spoligotyping) were linked to the 2000 National Health Survey (ENSA2000), a national probabilistic, polystage, stratified, cluster household survey of the civilian, noninstitutionalized population of Mexico.

RESULTS—From March 1995 to March 2003, 581 patients with Mycobacterium tuberculosis culture and fingerprint were diagnosed, 29.6% of whom had been diagnosed previously with diabetes by a physician. According to the ENSA2000, the estimated prevalence of diabetes in the study area was 5.3% (95% CI 4.1–6.5). The estimated rates of tuberculosis for the study area were greater for patients with diabetes than for nondiabetic individuals (209.5 vs. 30.7 per 100,000 person-years, P < 0.0001).

CONCLUSIONS—In this setting, the rate of tuberculosis was increased 6.8-fold (95% CI 5.7–8.2, P < 0.0001) in patients with diabetes due to increases in both reactivated and recently transmitted infection. Comorbidity with diabetes may increase tuberculosis rates as much as coinfection with human immunodeficiency virus (HIV), with important implications for the allocation of health care resources.

Abbreviations: ENSA2000, 2000 National Health Survey • RFLP, restriction fragment-length polymorphism


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
B. I. Restrepo, S. P. Fisher-Hoch, B. Smith, S. Jeon, M. H. Rahbar, J. B. McCormick, and the Nuevo Santander Tuberculosis Trackers
Mycobacterial Clearance from Sputum Is Delayed during the First Phase of Treatment in Patients with Diabetes
Am J Trop Med Hyg, October 1, 2008; 79(4): 541 - 544.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
G. W. Martens, M. C. Arikan, J. Lee, F. Ren, D. Greiner, and H. Kornfeld
Tuberculosis Susceptibility of Diabetic Mice
Am. J. Respir. Cell Mol. Biol., November 1, 2007; 37(5): 518 - 524.
[Abstract] [Full Text] [PDF]

Home page
 Chronic IllnessHome page
C. R. Stevenson, J. A. Critchley, N. G. Forouhi, G. Roglic, B. G. Williams, C. Dye, and N. C. Unwin
Diabetes and the risk of tuberculosis: a neglected threat to public health?
Chronic Illness, September 1, 2007; 3(3): 228 - 245.
[Abstract] [PDF]

Home page
 Am J Trop Med HygHome page
A. PEREZ, H. S. BROWN III, and B. I. RESTREPO
ASSOCIATION BETWEEN TUBERCULOSIS AND DIABETES IN THE MEXICAN BORDER AND NON-BORDER REGIONS OF TEXAS
Am J Trop Med Hyg, April 1, 2006; 74(4): 604 - 611.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
M-E Jimenez-Corona, L Garcia-Garcia, K DeRiemer, L Ferreyra-Reyes, M Bobadilla-del-Valle, B Cano-Arellano, S Canizales-Quintero, A Martinez-Gamboa, P M Small, J Sifuentes-Osornio, et al.
Gender differentials of pulmonary tuberculosis transmission and reactivation in an endemic area
Thorax, April 1, 2006; 61(4): 348 - 353.
[Abstract] [Full Text] [PDF]

Home page
 JRSMHome page
M. Waterhouse, C. Wilson, V. L C White, and T. A Chowdhury
Resolution of insulin-requiring diabetes after cessation of chemotherapy for tuberculosis
J R Soc Med, June 1, 2005; 98(6): 270 - 271.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2004 by the American Diabetes Association.