HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lorenzo, C. Articles by Haffner, S. M. Search for Related Content PubMed PubMed Citation Articles by Lorenzo, C. Articles by Haffner, S. M. Social Bookmarking                What's this?

The Prevalence of the Metabolic Syndrome Did Not Increase in Mexico City Between 1990–1992 and 1997–1999 Despite More Central Obesity

¹ Department of Clinical Epidemiology, University of Texas Heath Science Center, San Antonio, Texas
² Centro de Estudios en Diabetes, Centro de Investigacion en Salud Poblacional, Instituto Nacional de la Salud Publica, Instituto Mexicano del Seguro Social, American British Cowdray Medical Center, Mexico City, Mexico

Address correspondencereprint requests to Carlos Lorenzo, MD, Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78284-7873. E-mail: lorenzo{at}uthscsa.edu

OBJECTIVE—Trends in the metabolic syndrome might follow trends in obesity. We examined this hypothesis in the Mexico City Diabetes Study (MCDS), a study that showed rising trends in obesity, and the effect of the metabolic syndrome on the risk of coronary heart disease (CHD).

RESEARCH DESIGN AND METHODS—Designed as a population-based study, the MCDS enrolled subjects in 1990–1992 (n = 2,282). Follow-up visits were held in 1993–1995 (n = 1,764) and 1997–1999 (n = 1,754). We used the revised metabolic syndrome definition of the National Cholesterol Education Program and the Framingham equations to estimate the 10-year CHD risk.

RESULTS—In men, the age-adjusted prevalence of the metabolic syndrome was 38.9% in 1990–1992, 43.4% in 1993–1995, and 39.9% in 1997–1999; in women, the prevalences were 65.4, 65.7, and 59.9%, respectively. The prevalence did not change in men (P = 0.349) between 1990–1992 and 1997–1999, but decreased in women (P < 0.001). A prevalence increase was demonstrated for elevated waist circumference (men, P < 0.001; women, P < 0.050), elevated fasting glucose value (men and women, P < 0.001), and low HDL cholesterol level (men, P < 0.050; women, P < 0.010); a prevalence decrease was seen for high blood pressure (men and women, P < 0.001) and hypertriglyceridemia (men, P < 0.001; women, P < 0.010). CHD risk decreased marginally in men (P < 0.050) but did not change in women (P = 0.943).

CONCLUSIONS—Neither the prevalence of the metabolic syndrome nor CHD risk has increased in Mexico City. Lower blood pressure and triglyceride values appear to have counteracted increases in central obesity and fasting glucose.

Abbreviations: CHD, coronary heart disease • MCDS, Mexico City Diabetes Study • NHANES, National Health and Nutrition Examination Survey

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				R. J Kaaja Metabolic syndrome and the menopause Menopause Int, March 1, 2008; 14(1): 21 - 25. [Abstract] [Full Text] [PDF]

				G. Hu, J. Lindstrom, P. Jousilahti, M. Peltonen, L. Sjoberg, R. Kaaja, J. Sundvall, and J. Tuomilehto The Increasing Prevalence of Metabolic Syndrome among Finnish Men and Women over a Decade J. Clin. Endocrinol. Metab., March 1, 2008; 93(3): 832 - 836. [Abstract] [Full Text] [PDF]

				C. Schindler Review: The metabolic syndrome as an endocrine disease: is there an effective pharmacotherapeutic strategy optimally targeting the pathogenesis? Therapeutic Advances in Cardiovascular Disease, October 1, 2007; 1(1): 7 - 26. [Abstract] [PDF]

				E. Ferrannini Metabolic Syndrome: A Solution in Search of a Problem J. Clin. Endocrinol. Metab., February 1, 2007; 92(2): 396 - 398. [Full Text] [PDF]

				E. Bruckert Epidemiology of low HDL-cholesterol: results of studies and surveys Eur. Heart J. Suppl., October 1, 2006; 8(suppl_F): F17 - F22. [Abstract] [Full Text] [PDF]

				C. Lorenzo, K. Williams, K. J. Hunt, and S. M. Haffner Trend in the prevalence of the metabolic syndrome and its impact on cardiovascular disease incidence: the san antonio heart study. Diabetes Care, March 1, 2006; 29(3): 625 - 630. [Abstract] [Full Text] [PDF]