HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Erratum (v28,p990) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager patientINFORMation Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Clausen, T. D. Articles by Damm, P. Search for Related Content PubMed PubMed Citation Articles by Clausen, T. D. Articles by Damm, P. Social Bookmarking                What's this?

Poor Pregnancy Outcome in Women With Type 2 Diabetes

¹ Department of Obstetrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
² Department of Medical Endocrinology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
³ Steno Diabetes Center, Gentofte, Denmark
⁴ Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden

Address correspondence and reprint requests to Tine Dalsgaard Clausen, MD, Department of Obstetrics, 4031, The Juliane Marie Centre Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9 DK-2100, Copenhagen Ø, Denmark. E-mail: tine.clausen{at}rh.dk

OBJECTIVE— To evaluate the perinatal outcome and the frequency of maternal complications in pregnancies of women with type 2 diabetes during 1996–2001.

RESEARCH DESIGN AND METHODS— Medical records of 61 consecutive singleton pregnancies in women with type 2 diabetes from 1996 to 2001 were studied. Pregnancy outcome was compared with that of pregnant women with type 1 diabetes during 1996–2000, the background population, and pregnant women with type 2 diabetes during 1980–1992 from the same department.

RESULTS— The perinatal mortality in pregnancies complicated by type 2 diabetes (4/61, 6.6%) was increased four- and ninefold, respectively, and the rate of major congenital malformations (4/60, 6.7%) was more than doubled, although not statistically significant, compared with type 1 diabetic pregnancies and the background population. The glycemic control was similar or better in women with type 2 diabetes compared with women with type 1 diabetes. Multivariate logistic regression analysis in the pooled group of pregnancies with pregestational diabetes from 1996 to 2001 showed that high HbA_1c at admission and type 2 diabetes were independently associated with a serious adverse fetal outcome (perinatal mortality and/or major congenital malformations). The perinatal mortality and the rate of major congenital malformations in type 2 diabetic pregnancies have increased during the last decade.

CONCLUSIONS— The perinatal outcome of pregnancies in women with type 2 diabetes during 1996–2001 is poor. It is worse than the outcome of pregnancies in women with type 1 diabetes and the background population in the same period, as well as in women with type 2 diabetes studied during 1982–1990.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

Find additional patient-related information at:

Health Problems in Babies of Diabetic Mothers

This article has been cited by other articles:

				J. L. Kitzmiller, J. M. Block, F. M. Brown, P. M. Catalano, D. L. Conway, D. R. Coustan, E. P. Gunderson, W. H. Herman, L. D. Hoffman, M. Inturrisi, et al. Managing Preexisting Diabetes for Pregnancy: Summary of evidence and consensus recommendations for care Diabetes Care, May 1, 2008; 31(5): 1060 - 1079. [Full Text] [PDF]

				H. R. Murphy, G. Rayman, K. Duffield, K. S. Lewis, S. Kelly, B. Johal, D. Fowler, and R. C. Temple Changes in the Glycemic Profiles of Women With Type 1 and Type 2 Diabetes During Pregnancy Diabetes Care, November 1, 2007; 30(11): 2785 - 2791. [Abstract] [Full Text] [PDF]

				T. Cundy, G. Gamble, L. Neale, R. Elder, P. McPherson, P. Henley, and J. Rowan Differing Causes of Pregnancy Loss in Type 1 and Type 2 Diabetes Diabetes Care, October 1, 2007; 30(10): 2603 - 2607. [Abstract] [Full Text] [PDF]

				P. Damm, E. R. Mathiesen, K. R. Petersen, and S. Kjos Contraception After Gestational Diabetes Diabetes Care, July 1, 2007; 30(Supplement_2): S236 - S241. [Full Text] [PDF]

				S. Ullmo, Y. Vial, S. Di Bernardo, M. Roth-Kleiner, Y. Mivelaz, N. Sekarski, J. Ruiz, and E. J Meijboom Pathologic ventricular hypertrophy in the offspring of diabetic mothers: a retrospective study Eur. Heart J., June 1, 2007; 28(11): 1319 - 1325. [Abstract] [Full Text] [PDF]

				J. M. Slocum Preconception Counseling and Type 2 Diabetes Diabetes Spectr, April 1, 2007; 20(2): 117 - 123. [Full Text] [PDF]

				N. Hillman, L. Herranz, P. M. Vaquero, A. Villarroel, A. Fernandez, and L. F. Pallardo Is pregnancy outcome worse in type 2 than in type 1 diabetic women? Diabetes Care, November 1, 2006; 29(11): 2557 - 2558. [Full Text] [PDF]

				M. C M Macintosh, K. M Fleming, J. A Bailey, P. Doyle, J. Modder, D. Acolet, S. Golightly, and A. Miller Perinatal mortality and congenital anomalies in babies of women with type 1 or type 2 diabetes in England, Wales, and Northern Ireland: population based study BMJ, July 22, 2006; 333(7560): 177. [Abstract] [Full Text] [PDF]

				E. B. Schwarz, J. Maselli, and R. Gonzales Contraceptive Counseling of Diabetic Women of Reproductive Age. Obstet. Gynecol., May 1, 2006; 107(5): 1070 - 1074. [Abstract] [Full Text] [PDF]

				G. D. Harris and R. D. White Diabetes Management and Exercise in Pregnant Patients With Diabetes Clin. Diabetes, October 1, 2005; 23(4): 165 - 168. [Abstract] [Full Text] [PDF]