|
 |
|
|||||||
|
|||||||||
© 2005 by the American Diabetes Association, Inc.
Clinical Care/Education/Nutrition |
Caffeine Ingestion Is Associated With Reductions in Glucose Uptake Independent of Obesity and Type 2 Diabetes Before and After Exercise Training
1 School of Physical and Health Education, Queen’s University, Kingston, Ontario, Canada
2 Department of Medicine, Division of Endocrinology and Metabolism, Queen’s University, Kingston, Ontario, Canada
3 Department of Medicine, Division of Geriatrics, Queen’s University, Kingston, Ontario, Canada
4 Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Address correspondence and reprint requests to Robert Ross, PhD, School of Physical and Health Education, Queen’s University, Kingston, Ontario, Canada, K7L 3N6. E-mail: rossr{at}post.queensu.ca
OBJECTIVE—We investigated the effect of caffeine ingestion on insulin sensitivity in sedentary lean men (n = 8) and obese men with (n = 7) and without (n = 8) type 2 diabetes. We also examined whether chronic exercise influences the relationship between caffeine and insulin sensitivity in these individuals.
RESEARCH DESIGN AND METHODS—Subjects underwent two hyperinsulinemic-euglycemic clamp procedures, caffeine (5 mg/kg body wt) and placebo, in a double-blind, randomized manner before and after a 3-month aerobic exercise program. Body composition was measured by magnetic resonance imaging.
RESULTS—At baseline, caffeine ingestion was associated with a significant reduction (P < 0.05) in insulin sensitivity by a similar magnitude in the lean (33%), obese (33%), and type 2 diabetic (37%) groups in comparison with placebo. After exercise training, caffeine ingestion was still associated with a reduction (P < 0.05) in insulin sensitivity by a similar magnitude in the lean (23%), obese (26%), and type 2 diabetic (36%) groups in comparison with placebo. Exercise was not associated with a significant increase in insulin sensitivity in either the caffeine or placebo trials, independent of group (P > 0.10).
CONCLUSIONS—Caffeine consumption is associated with a substantial reduction in insulin-mediated glucose uptake independent of obesity, type 2 diabetes, and chronic exercise.
Abbreviations: FFA, free fatty acid
CiteULike 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Find additional patient-related information at:
This article has been cited by other articles:
|
|
 |
|
  D. S. Battram, T. E. Graham, and F. Dela Caffeine's impairment of insulin-mediated glucose disposal cannot be solely attributed to adrenaline in humans J. Physiol., September 15, 2007; 583(3): 1069 - 1077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Battram, J. Bugaresti, J. Gusba, and T. E. Graham Acute caffeine ingestion does not impair glucose tolerance in persons with tetraplegia J Appl Physiol, January 1, 2007; 102(1): 374 - 381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Norager, M. B. Jensen, M. R. Madsen, and S. Laurberg Caffeine improves endurance in 75-yr-old citizens: a randomized, double-blind, placebo-controlled, crossover study J Appl Physiol, December 1, 2005; 99(6): 2302 - 2306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Battram, T. E. Graham, E. A. Richter, and F. Dela The effect of caffeine on glucose kinetics in humans - influence of adrenaline J. Physiol., November 15, 2005; 569(1): 347 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lee, J. L. Kuk, L. E. Davidson, R. Hudson, K. Kilpatrick, T. E. Graham, and R. Ross Exercise without weight loss is an effective strategy for obesity reduction in obese individuals with and without Type 2 diabetes J Appl Physiol, September 1, 2005; 99(3): 1220 - 1225. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Diabetes | Diabetes Care | Clinical Diabetes | Diabetes Spectrum |