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Lipid Profile, Glucose Homeostasis, Blood Pressure, and Obesity-Anthropometric Markers in Macrosomic Offspring of Nondiabetic Mothers

¹ Neonatal Intensive Care Unit, University of Ioannina, Ioannina, Greece
² Department of Physiology, University of Ioannina, Ioannina, Greece
³ Laboratory of Biochemistry, University of Ioannina, Ioannina, Greece
⁴ Research Laboratory of Child Health Department, Medical School, University of Ioannina, Ioannina, Greece

Address correspondence and reprint requests to Vasileios Giapros, University Hospital of Ioannina, P.O. Box 1186, Ioannina 451 10, Greece. E-mail: vgiapros{at}cc.uoi.gr

OBJECTIVE—The study was to determine whether being the macrosomic offspring of a mother without detected glucose intolerance during pregnancy has an impact on lipid profile, glucose homeostasis, and blood pressure during childhood.

RESEARCH DESIGN AND METHODS—Plasma total, HDL, and LDL cholesterol; triglycerides; apolipoprotein (Apo) A-1, -B, and -E; lipoprotein (a); fasting glucose and insulin; homeostasis model assessment of insulin resistance (HOMA-IR) index; blood pressure; BMI; and detailed anthropometry were evaluated in 85 children aged 3–10 years old, born appropriate for gestational age (AGA; n = 48) and large for gestational age (LGA; n = 37) of healthy mothers.

RESULTS—At the time of the assessment, body weight, height, skinfold thickness, BMI, waist circumference, and blood pressure did not differ between the LGA and AGA groups with the exception of head circumference (P < 0.01). There were no significant differences in plasma total or LDL cholesterol; triglycerides; Apo A-1, -B, or -E; lipoprotein (a); Apo B–to–Apo A-1 ratio; or glucose levels between the groups. The LGA group had significantly higher HDL cholesterol levels (P < 0.01), fasting insulin levels (P < 0.01), and HOMA-IR index (P < 0.01) but lower values of the glucose-to-insulin ratio (P < 0.01) as compared with the AGA group.

CONCLUSIONS—Children born LGA of mothers without confirmed impaired glucose tolerance during pregnancy show higher insulin concentrations than AGAs.

Abbreviations: AGA, appropriate for gestational age • Apo, apolipoprotein • GDM, gestational diabetes mellitus • HOMA-IR, homeostasis model assessment of insulin resistance • LGA, large for gestational age

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