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Declining Death Rates From Hyperglycemic Crisis Among Adults With Diabetes, U.S., 1985–2002

From the Division of Diabetes Translation, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, Georgia

Address correspondence and reprint requests to Jing Wang, MPh, Northrop Grumman Contractor, Division of Diabetes Translation, Centers for Disease Control and Prevention, 4770 Buford Hwy., N.E. Mailstop K-10, Atlanta, GA 30341. E-mail: zrr4{at}cdc.gov

OBJECTIVE—To examine trends in death rates for hyperglycemic crisis (diabetic ketoacidosis or hyperglycemic hyperosmolar state) among adults with diabetes in the U.S. from 1985 to 2002.

RESEARCH DESIGN AND METHODS—Deaths with hyperglycemic crisis as the underlying cause were identified from national mortality data. Death rates were calculated using estimates of adults with diabetes from the National Health Interview Survey as the denominator and age adjusted to the 2000 U.S. population. The trends from 1985 to 2002 were tested using joinpoint regression analysis.

RESULTS—Deaths due to hyperglycemic crisis dropped from 2,989 in 1985 to 2,459 in 2002. During the time period, age-adjusted death rates decreased from 42.4 to 23.8 per 100,000 adults with diabetes (4.4% decrease per year, P for trend <0.01). Death rates declined in all age-groups, with the greatest decrease occurring among individuals aged 65 years. Age-adjusted death rates fell for all race-sex subgroups, with black men experiencing the smallest decline. About one-fifth of deaths occurred at home or on arrival at the hospital, and the death rates for hyperglycemic crisis occurring at these places declined only modestly over time (2.1% decrease per year, P for trend = 0.049).

CONCLUSIONS—Overall death rates due to hyperglycemic crisis among adults with diabetes have declined in the U.S. However, scope for further improvement remains, especially to further reduce death rates among black men and to prevent deaths occurring at home.

Abbreviations: DKA, diabetic ketoacidosis • HHS, hyperglycemic hyperosmolar state

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