Diabetes Care, Vol 3, Issue 2 309-313, Copyright © 1980 by American Diabetes Association
Control of insulin-dependent diabetes with portable miniaturized infusion systems
KD Hepp, R Renner, K Piwernetz and H Mehnert
A method of insulin therapy that appears to achieve better control of diabetes than present conventional methods is the use of insulin infusion devices--either glucose-controlled feedback (closed-loop) systems or the preprogrammed (open-loop) infusion pump. In view of the problems with implantable glucose sensors, we have worked to develop a miniaturized, programmable infusion system. Its use in insulin-dependent diabetic patients to provide either intravenous doses or a continuous subcutaneous insulin infusion resulted in significant reductions in blood glucose levels, glycemic excursions and 24-h glucose excretion.
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