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Published online July 20, 2007
Diabetes Care 30:2599-2602, 2007
DOI: 10.2337/dc07-0922
© 2007 by the American Diabetes Association
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Pathophysiology/Complications
Original Article

Carotid Intima-Media Thickness in Pediatric Type 1 Diabetic Patients

Rocio Rabago Rodriguez, MD1, Rita A. Gómez-Díaz, MD2, Janet Tanus Haj, MD3, Francisco Jose Avelar Garnica, MD3, Eleazar Ramirez Soriano, MD1, Elisa Nishimura Meguro, MD1, Carlos A. Aguilar-Salinas, MD4 and Niels H. Wacher, MD, PHD2

1 Servicio de Endocrinología, UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico
2 Unidad de Investigación Médica en Epidemiología Clínica, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico
3 Servicio de Radiodiagnóstico, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico
4 Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico

Address correspondence and reprint requests to Rita Angélica Gómez-Díaz, Unidad de Investigación Médica en Epidemiología Clínica, UMAE Hospital de Especialidades, CMN-SXXI, IMSS, Av. Cuauhtémoc #330, Col. Doctores, Deleg. Cuauhtémoc, 06725 México, D.F., México. E-mail: ritagomezdiaz{at}netscape.net

OBJECTIVE—To compare the carotid artery intima-media thickness in Hispanic pediatric type 1 diabetic patients against that in healthy control subjects matched for age, sex, height, and BMI.

RESEARCH DESIGN AND METHODS—The evaluation consisted of anthropometric measurements, biochemical parameters, and a carotid Doppler and real-time ultrasound, in which carotid artery intima-media thickness (cIMT), peak systolic velocity, and end diastolic velocity were measured using standardized procedures.

RESULTS—A total of 52 diabetic patients and 47 control subjects were included. No significant differences existed in the characteristics between case and control subjects (mean age 11.8 ± 3.1 vs. 11.8 ± 2.8 years, weight 42.2 ± 15.3 vs. 44.2 ± 14.4 kg, height 1.45 ± 0.15 vs. 1.47 ± 0.15 m, BMI 19.3 ± 3.2 vs. 19.9 ± 4.4 kg/m2, systolic blood pressure 99.1 ± 9.9 vs. 99.6 ± 9 mmHg, and diastolic blood pressure 63 ± 6.4 vs. 62.0 ± 5.7 mmHg, respectively). The mean duration of diabetes was 4.8 ± 3.2 years (range 6–144 months), and the mean A1C was 8.6 ± 1.6%. A significantly higher cIMT was found in the patients with type 1 diabetes (0.463 ± 0.04 vs. 0.441 ± 0.04 mm; P = 0.001). In contrast, both peak systolic velocity (107.1 ± 22.8 vs. 119.3 ± 19.2, P < 0.005) and end diastolic velocity (28.4 ± 6.0 vs. 33.0 ± 7.0, P < 0.001) were higher in the control subjects.

CONCLUSIONS—Type 1 diabetes is associated with higher cIMT and decreased flow velocities in a Hispanic pediatric population.

Abbreviations: CHD, coronary heart disease • cIMT, carotid artery intima-media thickness


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