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Published online July 10, 2007
Diabetes Care 30:2690-2694, 2007
DOI: 10.2337/dc07-0315
© 2007 by the American Diabetes Association
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Cardiovascular and Metabolic Risk
Original Article

Relationship Among Alcohol, Body Weight, and Cardiovascular Risk Factors in 27,030 Korean Men

Ki-Chul Sung, MD1, Sun H. Kim, MD2 and Gerald M. Reaven, MD2

1 Department of Medicine, Sungkyunkwan University, Kangbuk Samsung Hospital, Seoul, Korea
2 Department of Medicine, Stanford University School of Medicine, Stanford, California

Address correspondence and reprint requests to Sun H. Kim, MD, Stanford University Medical Center, 300 Pasteur Dr., Room S025, Stanford, CA 94305-5103. E-mail: sunhkim{at}stanford.edu

OBJECTIVE— Recent studies suggest a lower risk for overweight/obesity in moderate alcohol drinkers. However, the validity of this relationship and its impact on the putative benefits of alcohol consumption on cardiovascular disease (CVD) risk has not been well evaluated.

RESEARCH DESIGN AND METHODS— We assessed the impact of BMI on the relationship between alcohol consumption and CVD risk factors (blood pressure, lipid panel, and glucose and insulin concentrations) in 27,030 healthy Korean men with no major comorbidities or medication intake seen in a large urban Korean hospital.

RESULTS— BMI and overweight prevalence increased linearly with alcohol intake (P < 0.001). Alcohol intake was also positively associated with blood pressure and triglyceride, HDL, and fasting glucose concentrations (P < 0.001) and negatively associated with LDL and insulin concentrations (P < 0.001). With nondrinkers as the reference group, the odds ratio for having insulin in the top quartile also declined linearly when adjusted for age, BMI, smoking, and exercise, with the heaviest drinkers (>40 g/day) having an odds ratio of 0.71 (95% CI 0.62–0.82) (P < 0.001). The relationship between alcohol and CVD risk factors was similar in normal-weight and overweight individuals.

CONCLUSIONS— Alcohol intake is associated with increasing BMI and several metabolic abnormalities, including higher fasting glucose. Paradoxically, it is also associated with lower insulin concentrations. The clinical significance of these findings needs further investigation.

Abbreviations: CVD, cardiovascular disease


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