HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Online-Only Appendix All Versions of this Article: dc07-0050v1 30/10/2700    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kelly, L. A. Articles by Goran, M. I. Search for Related Content PubMed PubMed Citation Articles by Kelly, L. A. Articles by Goran, M. I. Social Bookmarking                What's this?

Parental History and Risk of Type 2 Diabetes in Overweight Latino Adolescents

A longitudinal analysis

¹ Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
² Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California
³ Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California

Address correspondence and reprint requests to Professor Michael I. Goran, PhD, 2250 Alcazar St., Los Angeles, CA 90089-9008. E-mail: goran{at}usc.edu

OBJECTIVE— The purpose of this article was to examine metabolic risk factors for type 2 diabetes in children and adolescents as a function of maternal versus paternal family history of type 2 diabetes and to examine whether differences in these risk factors emerge during adolescent growth.

RESEARCH DESIGN AND METHODS— A total of 247 overweight Latino children (baseline age = 11.1 ± 1.7 years) with a parental history of type 2 diabetes were followed annually for 5 years (2.2 ± 1.2 observations/child) with measures of insulin sensitivity, acute insulin response to glucose, and disposition index. Longitudinal linear mixed-effects modeling was used to evaluate the influence of maternal versus paternal family history of type 2 diabetes on changes in diabetes risk factors over age.

RESULTS— Insulin sensitivity and the disposition index decreased over age (ß = –0.052 and ß = –0.033, P < 0 0.01). Acute insulin response to glucose and fasting and 2-h glucose increased (ß = 0.019, ß = 0.002, and ß = 0.003, P < 0.01). Declines in insulin sensitivity were significantly greater in participants whose maternal grandmothers had a history of type 2 diabetes (ß = –0.03, P = 0.03). Declines in the disposition index (ß = –0.02, P = 0.04) and increases in fasting glucose were significantly influenced by a maternal history of type 2 diabetes (ß = 0.60, P < 0.05).

CONCLUSIONS— Maternal but not paternal family history for diabetes may have a significant impact on insulin dynamics, becoming more pronounced during growth in overweight Latino adolescents. Further research is clearly warranted.

Abbreviations: FSIVGTT, frequently sampled intravenous glucose tolerance test • mtDNA, mitochondrial DNA • OGTT, oral glucose tolerance test

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?