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Screening for Coronary Artery Disease in Patients With Diabetes

¹ Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands
² Departments of Medicine and Physiology, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut
³ Department of Medicine, Cardiovascular Division, Mayo Clinic College of Medicine, Rochester, Minnesota
⁴ Department of Medicine, Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
⁵ Department of Medicine, Division of Endocrinology and Metabolism, Indiana University, Indianapolis, Indiana
⁶ Department of Medicine, Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, Virginia

Address correspondence and reprint requests to Eugene Barrett, MD, PhD, University of Virginia, Box 801410, Charlottesville, VA 22903. E-mail: ejb8x{at}virginia.edu

Coronary artery disease (CAD) accounts for a large fraction of the morbidity, mortality, and cost of diabetes. Recognizing this, nearly 10 years ago the American Diabetes Association published a consensus recommendation that clinicians consider a risk factor–guided screening approach to early diagnosis of CAD in both symptomatic and asymptomatic patients. Subsequent clinical trial results have not supported those recommendations. Since the prior consensus statement, newer imaging methods, such as coronary artery calcium scoring and noninvasive angiography with computed tomography (CT) techniques, have come into use. These technologies, which allow quantitation of atherosclerotic burden and can predict risk of cardiac events, might provide an approach to more widespread coronary atherosclerosis screening. However, over this same time interval, there has been recognition of diabetes as a cardiovascular disease (CVD) equivalent, clear demonstration that medical interventions should provide primary and secondary CVD risk reduction in diabetic populations, and suggestive evidence that percutaneous coronary revascularization may not provide additive survival benefit to intensive medical management in patients with stable CAD. This additional evidence raises the question of whether documenting asymptomatic atherosclerosis or ischemia in people with diabetes is warranted. More data addressing this issue will be forthcoming from the BARI 2-D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial. Until then, for patients with type 2 diabetes who are asymptomatic for CAD, we recommend that testing for atherosclerosis or ischemia, perhaps with cardiac CT as the initial test, be reserved for those in whom medical treatment goals cannot be met and for selected individuals in whom there is strong clinical suspicion of very-high-risk CAD. Better approaches to identify such individuals based on readily obtained clinical variables are sorely needed.

Abbreviations: ADA, American Diabetes Association • CAD, coronary artery disease • CT, computed tomography • CVD, cardiovascular disease • ECG, electrocardiogram • MI, myocardial infarction

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