HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: dc07-0869v1 30/11/2863    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Porchay-Baldérelli, I. Search for Related Content PubMed PubMed Citation Articles by Porchay-Baldérelli, I. Social Bookmarking                What's this?

The CETP TaqIB Polymorphism Is Associated With the Risk of Sudden Death in Type 2 Diabetic Patients

¹ Institut National de la Santé et de la Recherche Médicale, U695, Genetic Determinants for Type 2 Diabetes and Its Vascular Complications, Paris, France
² University Paris-Diderot, Paris 7, Paris, France
³ Department of Endocrinology, Diabetology, Nutrition and Metabolic Diseases, Assistance Publique-Hôpitaux de Paris, Xavier Bichat Hospital, Paris, France

Address correspondence and reprint requests to F. Fumeron, INSERM, U695, Xavier Bichat Medical School, BP 416, 16 rue Henri Huchard, 75870 Paris cedex 18, France. E-mail: fumeron{at}bichat.inserm.fr

OBJECTIVE—Type 2 diabetic patients have a high risk of coronary heart disease (CHD) and sudden death. This cardiovascular risk can be partly attributed to low levels of HDL cholesterol. The B2 allele of the CETP TaqIB polymorphism has been repeatedly reported to be associated with high HDL cholesterol levels in both healthy and type 2 diabetic subjects, but its association with CHD is unclear. We investigated the association of the CETP TaqIB polymorphism with CHD, and sudden death in particular, in a prospective cohort of type 2 diabetic patients.

RESEARCH DESIGN AND METHODS—The CETP TaqIB polymorphism was genotyped in 3,124 type 2 diabetic subjects with high cardiovascular risk: the Noninsulin-Dependent Diabetes, Hypertension, Microalbuminuria, Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR) study. We used Cox regression analysis to estimate the impact of the TaqIB single nucleotide polymorphism on the CHD events (myocardial infarction or sudden death) during follow-up.

RESULTS—The incidence of CHD was higher in B1B1 homozygotes than in B2 carriers (P = 0.02). This effect was mainly due to sudden death (hazard ratio [B1B1 vs. B2⁺] = 1.51 [95% CI = 1.05–2.18]). Although the B1 allele was associated in a dose-dependent fashion with lower HDL cholesterol (P < 0.001), the association with sudden death persisted after adjustment for multiple risk factors, including HDL cholesterol levels.

CONCLUSIONS—In type 2 diabetic patients, the CETP TaqIB polymorphism is a good genetic predictor of cardiac mortality. This association is partly independent of the effect on HDL cholesterol levels.

Abbreviations: CHD, coronary heart disease • CETP, cholesteryl ester transfer protein • CRP, C-reactive protein • DIABHYCAR, Noninsulin-Dependent Diabetes, Hypertension, Microalbuminuria, Proteinuria, Cardiovascular Events, and Ramipril • SNP, single nucleotide polymorphism • UAE, urinary albumin excretion

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?