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Skeletal Muscle Deoxygenation After the Onset of Moderate Exercise Suggests Slowed Microvascular Blood Flow Kinetics in Type 2 Diabetes

¹ Division of Cardiology, University of Colorado at Denver and Health Sciences Center, Denver, Colorado
² Division of Endocrinology, University of Colorado at Denver and Health Sciences Center, Denver, Colorado
³ Denver VA Medical Center Denver, Colorado
⁴ Center for Women’s Health Research, Denver, Colorado
⁵ Division of Renal Disease, University of Colorado at Denver and Health Sciences Center, Denver, Colorado
⁶ Division of General Internal Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado

Address correspondence and reprint requests to Timothy Bayer, University of Colorado at Denver and Health Sciences Center, Leprino Office Building, 3rd Floor, Mail Stop B141, 12401 E. 17th Ave., Aurora, CO 80045

OBJECTIVE—People with type 2 diabetes have impaired exercise responses even in the absence of cardiovascular complications. One key factor associated with the exercise intolerance is abnormally slowed oxygen uptake (O₂) kinetics during submaximal exercise. The mechanisms of this delayed adaptation during exercise are unclear but probably relate to impairments in skeletal muscle blood flow. This study was conducted to compare skeletal muscle deoxygenation (deoxygenated hemoglobin/myoglobin [HHb]) responses and estimated microvascular blood flow (Qm) kinetics in type 2 diabetic and healthy subjects after the onset of moderate exercise.

RESEARCH DESIGN AND METHODS—Pulmonary O₂ kinetics and [HHb] (using near-infrared spectroscopy) were measured in 11 type 2 diabetic and 11 healthy subjects during exercise transitions from unloaded to moderate cycling exercise. Qm responses were calculated using O₂ kinetics and [HHb] responses via rearrangement of the Fick principle.

RESULTS—O₂ kinetics were slowed in type 2 diabetic compared with control subjects (43.8 ± 9.6 vs. 34.2 ± 8.2 s, P < 0.05), and the initial [HHb] response after the onset of exercise exceeded the steady-state level of oxygen extraction in type 2 diabetic compared with control subjects. The mean response time of the estimated Qm increase was prolonged in type 2 diabetic compared with healthy subjects (47.7 ± 14.3 vs. 35.8 ± 10.7 s, P < 0.05).

CONCLUSIONS—Type 2 diabetic skeletal muscle demonstrates a transient imbalance of muscle O₂ delivery relative to O₂ uptake after onset of exercise, suggesting a slowed Qm increase in type 2 diabetic muscle. Impaired vasodilatation due to vascular dysfunction in type 2 diabetes during exercise may contribute to this observation. Further study of the mechanisms leading to impaired muscle oxygen delivery may help explain the abnormal exercise responses in type 2 diabetes.

Abbreviations: CWR, constant work rate • [HHb], deoxygenated hemoglobin/myoglobin • MRT, mean response time • NIRS, near-infrared spectroscopy

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