Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online September 21, 2007
Diabetes Care 30:3125-3127, 2007
DOI: 10.2337/dc07-0457
© 2007 by the American Diabetes Association
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dc07-0457v1
30/12/3125    most recent
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Corpeleijn, E.
Right arrow Articles by Blaak, E. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Corpeleijn, E.
Right arrow Articles by Blaak, E. E.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Cardiovascular and Metabolic Risk
Original Research

Lifestyle Intervention and Adipokine Levels in Subjects at High Risk for Type 2 Diabetes

The Study on Lifestyle intervention and Impaired glucose tolerance Maastricht (SLIM)

Eva Corpeleijn, PHD1, Edith J.M. Feskens, PHD2,3, Eugène H.J.M. Jansen, PHD4, Marco Mensink, MD, PHD1, Wim H.M. Saris, MD, PHD1 and Ellen E. Blaak, PHD1

1 Human Biology, Nutrition and Toxicology Research Institute, Maastricht, the Netherlands
2 Human Nutrition, Wageningen University and Research Center, Wageningen, the Netherlands
3 Centre for Nutrition and Health, National Institute for Public Health and Environment, Bilthoven, the Netherlands
4 Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and Environment, Bilthoven, the Netherlands

Address correspondence and reprint requests to Eva Corpeleijn, PHD, Human Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, Netherlands. E-mail: e.corpeleijn{at}hb.unimaas.nl

OBJECTIVE—We investigated whether circulating adipokine concentrations can be altered by lifestyle intervention according to general recommendations in subjects at risk for diabetes as well as the potential of leptin, adiponectin, and resistin as biomarkers for lifestyle-induced improvements in glucose metabolism and insulin resistance.

RESEARCH DESIGN AND METHODS—In the Study on Lifestyle intervention and Impaired glucose tolerance Maastricht, 147 men and women with impaired glucose tolerance (IGT) were randomized to either a combined diet-and-exercise intervention or a control program. At baseline and after 1 year, an oral glucose tolerance test, an exercise test, and anthropometric measurements were performed. After 1 year, complete data of 103 subjects (50 intervention and 53 control subjects) were obtained.

RESULTS—Lifestyle intervention reduced plasma leptin concentrations (–14.2%) in IGT subjects but did not alter plasma adiponectin (–0.3%) or resistin (–6.5%) concentrations despite marked improvements in glucose tolerance and insulin resistance.

CONCLUSIONS—Changes in leptin concentration were related to improvements in insulin sensitivity independent of changes in body composition.

Abbreviations: HOMA-IR, homeostasis model assessment of insulin resistance • SLIM, Study on Lifestyle intervention and Impaired glucose tolerance Maastricht


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2007 by the American Diabetes Association.