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Serum Adiponectin and Renal Dysfunction in Men With Type 2 Diabetes

¹ Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
² Renal Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
³ Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
⁴ Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts

Address correspondence and reprint requests to Julie Lin, MD, MPH, Renal Division, Brigham and Women’s Hospital, 75 Francis St., Boston, MA 02115. E-mail: jlin11{at}partners.org

OBJECTIVE—Inflammation is associated with both chronic kidney dysfunction and type 2 diabetes. Adiponectin, a novel circulating anti-inflammatory protein made by adipocytes, has been reported to be lower in diabetic than nondiabetic subjects. In contrast, serum levels of adiponectin are elevated in end-stage renal disease. We sought to investigate the relation between adiponectin and mild to moderate renal dysfunction in men with type 2 diabetes.

RESEARCH DESIGN AND METHODS—Multivariate logistic regression was used to evaluate the relation between serum adiponectin concentrations and the presence of renal dysfunction (estimated glomerular filtration rate [eGFR] <60 ml/min per 1.73 m² by the four-variable Modification of Diet in Renal Disease equation) in participants with type 2 diabetes in the Health Professionals’ Follow-Up Study. A total of 733 men were included in this cross-sectional analysis.

RESULTS—Adiponectin was positively correlated with age (Spearman coefficient, r = 0.19, P < 0.001) and negatively correlated with weight (Spearman coefficient, r = –0.18, P < 0.001). Those with adiponectin in the second quartile or higher (>10 µg/ml) compared with those in the first quartile had a reduced odds for renal dysfunction (multivariate odds ratio 0.48 [95% CI 0.28–0.81]). These results were unchanged when serum lipids were included in the multivariate model.

CONCLUSIONS—We conclude that a higher serum adiponectin concentration is associated with reduced odds of moderate renal dysfunction in men with type 2 diabetes.

Abbreviations: eGFR, estimated glomerular filtration rate • HPFS, Health Professionals’ Follow-Up Study

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