Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Diabetes Care 30:275-279, 2007
DOI: 10.2337/dc06-1399
© 2007 by the American Diabetes Association
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Errera, F. I.V.
Right arrow Articles by Passos-Bueno, M. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Errera, F. I.V.
Right arrow Articles by Passos-Bueno, M. R.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Pathophysiology/Complications
Original Article

Functional Vascular Endothelial Growth Factor –634G>C SNP Is Associated With Proliferative Diabetic Retinopathy

A case-control study in a Brazilian population of European ancestry

Flavia I.V. Errera, PHD1,2, Luís Henrique Canani, MD, PHD3, Maria Elisabeth R. Silva, MD, PHD4, Erika Yeh1, Walter Takahashi, MD, PHD5, Katia G. Santos, PHD6, Katia E.P. Souto, PHD7, Balduíno Tschiedel, MD, PHD7, Israel Roisenberg, MD, PHD6, Jorge Luis Gross, MD, PHD3 and Maria Rita Passos-Bueno, PHD1

1 Human Genome Center, Department of Genetics and Evolutive Biology, University of São Paulo, São Paulo, Brazil
2 Morphology Department, College of Health Science of Vitoria (EMESCAM), Vitória, Espírito Santo, Brazil
3 Endocrine Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
4 Laboratory of Medical Investigation LIM-18, Hospital das Clinicas of the University of São Paulo Medical School, São Paulo, Brazil
5 Ophthalmology Department, Hospital das Clinicas of the University of São Paulo Medical School, São Paulo, Brazil
6 Genetics Department, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
7 Endocrinology Division, Conceição Hospital, Porto Alegre, Brazil

Address correspondence and reprint requests to to Maria Rita Passos-Bueno, Rua do Matão, 277, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil, CEP 05508-900. E-mail: passos{at}ib.usp.br

OBJECTIVE—The purpose of this study was to evaluate the effect of the single nucleotide polymorphism (SNP) –634G>C at the 5' regulatory region of the vascular endothelial growth factor (VEGF) in the risk of proliferative diabetic retinopathy (PDR) in the Brazilian population of European ancestry with type 2 diabetes.

RESEARCH DESIGN AND METHODS—A case-control study was conducted in 501 type 2 diabetic patients of European ancestry. Patients underwent a standardized clinical, ophthalmological, and laboratory evaluation. Of these, 167 patients had PDR (case patients), and 334 were considered as control subjects (patients without PDR) for PDR. A reference population (110 individuals of European ancestry) was also evaluated.

RESULTS—No evidence of association between –634G>C/VEGF and the presence of diabetic retinopathy or type 2 diabetes was observed (P > 0.05). However, CC homozygous for the SNP –634G>C was significantly more frequent in patients with PDR (37 of 167; 22.2%) than in the corresponding control group (40 of 334; 12%) in accordance with a recessive model (P = 0.003). This effect was further observed when creatinine, BMI, sex, duration of type 2 diabetes, HDL cholesterol, and systolic blood pressure were taken into account (odds ratio 1.9 [95% CI 1.01–3.79], P = 0.04).

CONCLUSIONS—The presence of the allele –634C/VEGF in homozygosity is an independent risk factor for the development of PDR in type 2 diabetic patients of European ancestry.

Abbreviations: AAO, American Academy of Ophthalmology • NPDR, nonproliferative diabetic retinopathy • PDR, proliferative diabetic retinopathy • SNP, single nucleotide polymorphism • VEGF, vascular endothelial growth factor


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 JCOHome page
B. P. Schneider, M. Wang, M. Radovich, G. W. Sledge, S. Badve, A. Thor, D. A. Flockhart, B. Hancock, N. Davidson, J. Gralow, et al.
Association of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor-2 Genetic Polymorphisms With Outcome in a Trial of Paclitaxel Compared With Paclitaxel Plus Bevacizumab in Advanced Breast Cancer: ECOG 2100
J. Clin. Oncol., October 1, 2008; 26(28): 4672 - 4678.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. J. Churchill, J. G. Carter, C. Ramsden, S. J. Turner, A. Yeung, P. E. C. Brenchley, and D. W. Ray
VEGF Polymorphisms Are Associated with Severity of Diabetic Retinopathy
Invest. Ophthalmol. Vis. Sci., August 1, 2008; 49(8): 3611 - 3616.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2007 by the American Diabetes Association.