Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Diabetes Care 30:683-688, 2007
DOI: 10.2337/dc06-2032
© 2007 by the American Diabetes Association
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Perseghin, G.
Right arrow Articles by Luzi, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Perseghin, G.
Right arrow Articles by Luzi, L.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Pathophysiology/Complications
Original Article

Habitual Physical Activity Is Associated With Intrahepatic Fat Content in Humans

Gianluca Perseghin, MD1,2,3, Guido Lattuada, PHD1, Francesco De Cobelli, MD2,4, Francesca Ragogna, PHD1, Georgia Ntali, MD1, Antonio Esposito, MD4, Elena Belloni, MD4, Tamara Canu4, Ileana Terruzzi, PHD1, Paola Scifo, PHD5, Alessandro Del Maschio, MD2,4,6 and Livio Luzi, MD1,2,3

1 Internal Medicine, Section of Nutrition/Metabolism, San Raffaele Scientific Institute, Milan, Italy
2 Unit of Clinical Spectroscopy, San Raffaele Scientific Institute, Milan, Italy
3 Center "Physical Exercise for Health and Wellness," Faculty of Exercise Sciences, Università degli Studi di Milano, Milan, Italy
4 Diagnostic Radiology, San Raffaele Scientific Institute, Milan, Italy
5 Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy
6 Università Vita e Salute San Raffaele, Milan, Italy

Address correspondence and reprint requests to Gianluca Perseghin, MD, Faculty of Exercise Sciences, Università degli Studi di Milano and San Raffaele Scientific Institute, Internal Medicine, via Olgettina 60, 20132, Milan, Italy. E-mail: perseghin.gianluca{at}hsr.it

OBJECTIVE—Fatty liver may be involved in the pathogenesis of type 2 diabetes. Physical exercise is a tool to improve insulin sensitivity, but little is known about its effect on intrahepatic fat (IHF) content. The purpose of this study was to examine the association of habitual physical activity, insulin resistance, and adiponectin with IHF content.

RESEARCH DESIGN AND METHODS—Participants were 191 (77 female and 114 male) apparently healthy, nonalcoholic individuals (aged 19–62 years; BMI 17.0–35.5 kg/m2). IHF content was assessed in a quantitative fashion and noninvasively as a continuous variable by means of 1H magnetic resonance spectroscopy (MRS), and habitual physical activity was assessed by means of a questionnaire. Fatty liver was defined as IHF content of >5% wet weight, and insulin sensitivity was estimated using the computer homeostasis model assessment (HOMA)-2 indexes.

RESULTS—A reduced prevalence of fatty liver in the quartile of the most physically active individuals (25, 11, 25, and 2% in quartile 1, 2, 3, and 4, respectively; {chi}2 = 15.63; P = 0.001) was found along with an inverse correlation between the physical activity index and the IHF content when plotted as continuous variables (Pearson’s r = –0.27; P < 0.000). This association was not attenuated when adjusted for age, sex, BMI, HOMA-2, and adiponectin (partial correlation r = –0.25; P < 0.001).

CONCLUSIONS—This study demonstrated that a higher level of habitual physical activity is associated with a lower IHF content and suggested that this relationship may be due to the effect of exercise per se.

Abbreviations: FFA, free fatty acid • HOMA, homeostasis model assessment • HOMA2-%B, HOMA2-derived index of ß-cell insulin sensitivity • HOMA2-%S, HOMA2-derived index of insulin sensitivity • IHF, intrahepatic fat • MRS, magnetic resonance spectroscopy • NAFLD, nonalcoholic fatty liver disease • TSH, thyroid-stimulating hormone


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
R. S. Rector, J. P. Thyfault, R. T. Morris, M. J. Laye, S. J. Borengasser, F. W. Booth, and J. A. Ibdah
Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats
Am J Physiol Gastrointest Liver Physiol, March 1, 2008; 294(3): G619 - G626.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. Kotronen and H. Yki-Jarvinen
Fatty Liver: A Novel Component of the Metabolic Syndrome
Arterioscler. Thromb. Vasc. Biol., January 1, 2008; 28(1): 27 - 38.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Perseghin, G. Lattuada, F. De Cobelli, A. Esposito, E. Belloni, T. Canu, F. Ragogna, P. Scifo, A. Del Maschio, and L. Luzi
Serum Retinol-Binding Protein-4, Leptin, and Adiponectin Concentrations Are Related to Ectopic Fat Accumulation
J. Clin. Endocrinol. Metab., December 1, 2007; 92(12): 4883 - 4888.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Park, S. M. Hong, J. E. Lee, and S. R. Sung
Exercise improves glucose homeostasis that has been impaired by a high-fat diet by potentiating pancreatic beta-cell function and mass through IRS2 in diabetic rats
J Appl Physiol, November 1, 2007; 103(5): 1764 - 1771.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2007 by the American Diabetes Association.