Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online January 26, 2007
Diabetes Care 30:1156-1161, 2007
DOI: 10.2337/dc06-1153
© 2007 by the American Diabetes Association
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dc06-1153v1
30/5/1156    most recent
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vaccaro, O.
Right arrow Articles by Riccardi, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vaccaro, O.
Right arrow Articles by Riccardi, G.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Pathophysiology/Complications
Original Article

Pro12Ala Polymorphism of the PPAR{gamma}2 Locus Modulates the Relationship Between Energy Intake and Body Weight in Type 2 Diabetic Patients

Olga Vaccaro, MD1, Emanuela Lapice, MD1, Antonella Monticelli, MD2,3, Manuela Giacchetti, MCB2,3, Imma Castaldo, PHD2,3, Rocco Galasso, MD1, Michele Pinelli, MD2,3, Giovanna Donnarumma, MD1, Angela A. Rivellese, MD1, Sergio Cocozza, MD2,3 and Gabriele Riccardi, MD1

1 Department of Clinical and Experimental Medicine, University of Naples, Federico II, Naples, Italy
2 Department of Cellular and Molecular Biology and Pathology, "A. Califano" University, Federico II, Naples, Italy
3 Institute of Experimental Endocrinology and Oncology, National Council of Research, Naples, Italy

Address correspondence and reprint requests to Dr. Olga Vaccaro, Department of Clinical and Experimental Medicine, via S. Pansini 5, 80131 Naples, Italy. E-mail: ovaccaro{at}unina.it

OBJECTIVE—We explore the relationship among BMI, habitual diet, and the Pro12Ala polymorphism in the peroxisome proliferator–activated receptor (PPAR){gamma}2.

RESEARCH DESIGN AND METHODS—The Pro12Ala variant was characterized in 343 unrelated type 2 diabetic patients who were consecutively seen at the outpatient clinic of a health district of the province of Naples. Anthropometric and laboratory parameters were measured; habitual diet was assessed by a validated semiquantitative food frequency questionnaire.

RESULTS—The overall frequency of Ala12 was 12% (n = 42). BMI was significantly higher in Ala carriers than non-Ala carriers, whereas total daily energy intake or macronutrient composition of the diet were similar in the two groups. For further analysis, participants were stratified according to genotype and sex-specific quartiles of energy intake. BMI increased in both genotype groups with increasing energy intake (P < 0.03). BMI was similar in Ala carriers and non-Ala carriers (30.0 vs. 30.1 kg/m2, P > 0.10) in the lower quartile of energy intake but significantly higher in Ala carriers in the upper quartile (36.0 vs. 32.1 kg/m2, P < 0.001). Average daily energy intake and diet composition were comparable within each quartile for carriers or noncarriers of the Ala allele. Relative to the noncarriers, Ala carriers had a significantly lower energy intake per kilogram body weight, thus suggesting that the Ala allele is associated with a higher food efficiency. The confounding role of medications, glucose control, and physical exercise was ruled out.

CONCLUSIONS—This study provides evidence of a differential susceptibility to fat accumulation, and, hence, weight gain, in response to habitual high energy intake for Ala carriers compared with Pro/Pro homozygotes.

Abbreviations: PPAR, peroxisome proliferator–activated receptor • P/S, polyunsaturated-to-saturated fatty acid ratio


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2007 by the American Diabetes Association.