HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Online Only Appendix All Versions of this Article: dc06-2537v1 30/6/1507    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Park, S. W. Search for Related Content PubMed PubMed Citation Articles by Park, S. W. Social Bookmarking                What's this?

Accelerated Loss of Skeletal Muscle Strength in Older Adults With Type 2 Diabetes

The Health, Aging, and Body Composition Study

¹ Department of Internal Medicine, Pochon CHA University, Pochon, Korea
² Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania
³ Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
⁴ Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania
⁵ Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia
⁶ Laboratory for Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland
⁷ Department of Epidemiology and Biostatistics, University of California, San Francisco, California
⁸ Department of Preventive Medicine, University of Tennessee, Memphis, Tennessee

Address correspondence and reprint requests to Seok Won Park, MD, DrPH, Department of Internal Medicine, Pochon CHA University, 351 Yatap-dong, Sungnam, 463-712, Korea. E-mail: spark{at}cha.ac.kr

OBJECTIVE—It has been shown that adults with either long-standing type 1 or type 2 diabetes had lower skeletal muscle strength than nondiabetic adults in cross-sectional studies. The aim of the study was to investigate longitudinal changes of muscle mass and strength in community-dwelling older adults with and without type 2 diabetes.

RESEARCH DESIGN AND METHODS—We examined leg and arm muscle mass and strength at baseline and 3 years later in 1,840 older adults aged 70–79 years in the Health, Aging, and Body Composition Study. Regional muscle mass was measured by dual energy X-ray absorptiometry, and muscle strength was measured using isokinetic and isometric dynamometers.

RESULTS—Older adults with type 2 diabetes (n = 305) showed greater declines in the leg muscle mass (–0.29 ± 0.03 vs. –0.23 ± 0.01 kg, P < 0.05) and strength (–16.5 ± 1.2 vs. –12.4 ± 0.5 Nm, P = 0.001) compared with older adults without diabetes. Leg muscle quality, expressed as maximal strength per unit of muscle mass (Newton meters per kilogram), also declined more rapidly in older adults with diabetes (–1.6 ± 0.2 vs. –1.2 ± 0.1 Nm/kg, P < 0.05). Changes in arm muscle strength and quality were not different between those with and without diabetes. Rapid declines in leg muscle strength and quality were attenuated but remained significant after controlling for demographics, body composition, physical activity, combined chronic diseases, interleukin-6, and tumor necrosis factor-.

CONCLUSIONS—In older adults, type 2 diabetes is associated with accelerated loss of leg muscle strength and quality.

Abbreviations: Health ABC, Health, Aging, and Body Composition Study • IL-6, interleukin-6 • TNF-, tumor necrosis factor-

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S. F. E. Praet and L. J. C. van Loon Optimizing the therapeutic benefits of exercise in Type 2 diabetes J Appl Physiol, October 1, 2007; 103(4): 1113 - 1120. [Abstract] [Full Text] [PDF]