HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: dc06-2585v1 30/7/1789    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Schindhelm, R. K. Articles by Teerlink, T. Search for Related Content PubMed PubMed Citation Articles by Schindhelm, R. K. Articles by Teerlink, T. Social Bookmarking                What's this?

Fasting and Postprandial Glycoxidative and Lipoxidative Stress Are Increased in Women With Type 2 Diabetes

¹ Department of Endocrinology, Vrije University (VU) Medical Center, Amsterdam, the Netherlands
² Institute for Research in Extramural Medicine, VU Medical Center, Amsterdam, the Netherlands
³ Department of Clinical Chemistry, VU Medical Center, Amsterdam, the Netherlands
⁴ Department of General Practice, VU Medical Center, Amsterdam, the Netherlands
⁵ Department of Clinical Epidemiology and Biostatistics, VU Medical Center, Amsterdam, the Netherlands
⁶ Department of Internal Medicine, Academic Hospital Maastricht, Maastricht, the Netherlands

Address correspondence and reprint requests to T. Teerlink, PhD, VU University Medical Center, Clinical Chemistry, P.O. Box 7057, 1007 MB Amsterdam, Netherlands. E-mail: t.teerlink{at}vumc.nl

OBJECTIVE— We studied acute changes in markers of glycoxidative and lipoxidative stress, including oxidized LDL, N-(carboxyethyl)-lysine (CEL), N-(carboxymethyl)-lysine (CML), and 3-deoxyglucosone (3DG), following two consecutive meals.

RESEARCH DESIGN AND METHODS— Postmenopausal women (27 with normal glucose metabolism [NGM], 26 with type 2 diabetes) received two consecutive fat-rich meals and two consecutive carbohydrate-rich meals on two occasions. Glucose and triglyceride concentrations were measured at baseline and 1, 2, 4, 6, and 8 h following breakfast; lunch was given at 4 h. Oxidized LDL–to–LDL cholesterol ratio, CEL, CML, and 3DG were measured at baseline and at 8 h.

RESULTS— Fasting oxidized LDL–to–LDL cholesterol ratio, 3DG, and CML were higher in women with type 2 diabetes compared with women with NGM and were comparable to the postprandial values at 8 h in NGM. Postprandial rises in the oxidized LDL–to–LDL cholesterol ratio and 3DG were similar in both groups. However, the oxidized LDL–to–LDL cholesterol ratio increased more after the fat-rich meals, whereas CML and 3DG increased more after the carbohydrate-rich meals. After the fat-rich meals, the increase in the oxidized LDL–to–LDL cholesterol ratio correlated with postprandial triglycerides, whereas the increase in 3DG was correlated with postprandial glucose.

CONCLUSIONS— The acute changes in markers of glycoxidative and lipoxidative stress in both type 2 diabetes and NGM suggest that postabsorptive oxidative stress may partly underlie the association of postprandial derangements and cardiovascular risk.

Abbreviations: 3DG, 3-deoxyglucosone • AGE, advanced glycation end product • CAD, coronary artery disease • CEL, N-(carboxyethyl)-lysine • CML, N-(carboxymethyl)-lysine • CVD, cardiovascular disease • iAUC, incremental area under the curve • NGM, normal glucose metabolism

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?