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Published online October 31, 2007
Diabetes Care 31:322-324, 2008
DOI: 10.2337/dc07-1646
© 2008 by the American Diabetes Association
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Pathophysiology/Complications
Original Research

Squatting Amplifies Pulse Pressure Increase With Disease Duration in Patients With Type 1 Diabetes

Jean-Christophe Philips, MD, Monique Marchand and André J. Scheen, MD, PHD

From the 1Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, Centre Hospitalier Universitaire Sart Tilman, University of Liége, Liège, Belgium

Address correspondence and reprint requests to André J. Scheen, Diabetes, Nutrition and Metabolic Disorders Unit, C.H.U. Sart Tilman (B35), Liege 1 B-4000,Belgium. E-mail: andre.scheen{at}chu.ulg.ac.be

OBJECTIVE—To evaluate pulse pressure changes according to duration of type 1 diabetes and to assess the influence of posture.

RESEARCH DESIGN AND METHODS—We performed continuous measurement of blood pressure with a Finapres device during a 3 x 1 min posture test (standing, squatting, standing) in 159 type 1 diabetic patients divided into four groups according to diabetes duration (≤10, 11–20, 21–30, and >30 years, groups 1–4, respectively) and compared the results with those of age-matched nondiabetic subjects.

RESULTS—Pulse pressure progressively increased according to type 1 diabetes duration (P < 0.0001), especially in women, but not in age-matched nondiabetic subjects (NS). Pulse-pressure increase from group 1 to group 4 was amplified in the squatting position (from 50 ± 17 to 69 ± 14 mmHg) compared with standing (from 44 ± 15 to 55 ± 12 mmHg).

CONCLUSIONS—Pulse pressure increases according to type 1 diabetes duration more in women than in men, and the squatting position sensitizes such pulse-pressure increase in both sexes.

Abbreviations: CVD, cardiovascular disease • FinnDiane, Finnish Diabetic Nephropathy


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