Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online October 24, 2007
Diabetes Care 31:335-339, 2008
DOI: 10.2337/dc07-0874
© 2008 by the American Diabetes Association
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dc07-0874v1
31/2/335    most recent
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Carnethon, M. R.
Right arrow Articles by Daviglus, M. L.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carnethon, M. R.
Right arrow Articles by Daviglus, M. L.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Cardiovascular and Metabolic Risk
Original Research

Resting Heart Rate in Middle Age and Diabetes Development in Older Age

Mercedes R. Carnethon, PHD1, Lijing Yan, PHD1,2, Philip Greenland, MD1, Daniel B. Garside, BS1, Alan R. Dyer, PHD1, Boyd Metzger, MD3 and Martha L. Daviglus, MD, PHD1

1 Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
2 Department of Health Economics and Management, Guanghua School of Management, Peking University, Beijing, China
3 Department of Medicine (Endocrinology), Feinberg School of Medicine, Northwestern University, Chicago, Illinois

Address correspondence and reprint requests to Dr. Mercedes Carnethon, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N. Lake Shore Dr., Suite 1102, Chicago, IL 60611. E-mail: carnethon{at}northwestern.edu

OBJECTIVE—Based on prior research showing inverse associations between heart rate and life expectancy, we tested the hypothesis that adults with higher resting heart rate in middle age were more likely to have diagnosed diabetes or to experience diabetes mortality in older age (>65 years).

RESEARCH DESIGN AND METHODS—Resting heart rate was measured at baseline (1967–1973) in the Chicago Heart Association Detection Project in Industry. We used Medicare billing records to identify diabetes-related hospital claims and non–hospital-based diabetes expenses from 1992 to 2002 in 14,992 participants aged 35–64 years who were free from diabetes at baseline. Diabetes-related mortality was determined from 1984 to 2002 using National Death Index codes 250.XX (ICD-8 and -9) and E10–E14 (ICD-10).

RESULTS—After age 65, 1,877 participants had diabetes-related hospital claims and 410 participants had any mention of diabetes on their death certificate. The adjusted (demographic characteristics, cigarette smoking, and years of Medicare eligibility) odds of having a diabetes-related claim was ~10% higher (odds ratio [OR] 1.10 [95% CI 1.05–1.16]) per 12 bpm higher baseline heart rate. Following adjustment for BMI and postload glucose at baseline, the association attenuated to nonsignificance. Higher heart rate was associated with diabetes mortality in adults aged 35–49 years at baseline following adjustment for postload glucose and BMI (1.21 [1.03–1.41]).

CONCLUSIONS—Higher resting heart rate is associated with diabetes claims and mortality in older age and is only due in part to BMI and concurrently measured glucose.

Abbreviations: HRR, heart rate recovery


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2008 by the American Diabetes Association.